This study aimed to prospectively investigate the hypothesis that myocardial energy metabolism changes in the early stages of feline hypertrophic cardiomyopathy (HCM) by evaluating the blood carnitine profiles. Fourteen client owned cats with HCM stage B1 and 22 clinically healthy cats were included in this study. Total-carnitine, free-carnitine, acylcarnitine, and acylcarnitine/free-carnitine ratio (AF ratio) in serum were measured in both groups. No significant differences were observed in total-carnitine, free-carnitine, and acylcarnitine concentrations between the groups. However, the AF ratio in the HCM group was significantly lower than that of the control group (P=0.02). The lower serum AF ratio in cats with early-stage HCM, may suggest an alteration in their myocardial energy metabolism.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1292/jvms.24-0171 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Early Identification of Myocardial Microstructural Alterations in Hypertrophic Cardiomyopathy with in Vivo Cardiac Diffusion-Tensor Imaging.
Radiol Cardiothorac Imaging
February 2025
From the Department of Magnetic Resonance Imaging, Radiology Imaging Center, Fuwai Hospital, National Center for Cardiovascular Diseases, State Key Laboratory of Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical College, Beilishi Road No. 167, Xicheng District, Beijing 100037, China (Z.D., Y.T., G.Y., X.M., S.Y., J.W., X.X., K.Y., M.L., X.C., S.Z.); Clinical and Technical Support, Philips Healthcare, Beijing, China (P.S.); and Paul C. Lauterbur Research Center for Biomedical Imaging, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, SZ University Town, Shenzhen, China (K.Z., Y.Z.).
Purpose To explore the diffusion characteristics of hypertrophic cardiomyopathy (HCM) using in vivo cardiac diffusion-tensor imaging (cDTI) and to determine whether cDTI could help identify abnormal myocardium beyond cardiac MRI findings of fibrosis and hypertrophy. Materials and Methods In this prospective study conducted from April to August 2023, participants with HCM and healthy volunteers were enrolled for cardiac MRI evaluation, including cine, late gadolinium enhancement (LGE), T1 mapping, and cDT imaging, using a 3.0-T scanner.
View Article and Find Full Text PDFHypertrophic cardiomyopathy (HCM) is a genetic cardiac disorder associated with an increased risk of arrhythmias, heart failure, and sudden cardiac death. Current imaging and clinical markers are not fully sufficient in accurate diagnosis and patient risk stratification. Although known cardiac biomarkers in blood are used, they lack specificity for HCM and primarily stratify for death due to heart failure in overt cases.
View Article and Find Full Text PDFUnrecognized Inter-Coronary Communication in a Case of Hypertrophic Cardiomyopathy.
Discoveries (Craiova)
September 2024
Department of Cardiology, Rashid Hospital, Dubai, United Arab Emirates.
Inter-coronary communication is a rare congenital anomaly, defined as a connection between two patent coronary arteries, and was first described in 1972. We report the case of a 61-year-old Emirati female who presented to the emergency department with chest pain and palpitations, along with a strong family history of cardiac disease. She was initially diagnosed with indolent hypertrophic obstructive cardiomyopathy and accordingly managed; however, the patient remained symptomatic.
View Article and Find Full Text PDFHow to assess sudden cardiac death risk in hypertrophic cardiomyopathy? Current challenges and directions for the future.
Kardiol Pol
January 2025
1st Department of Cardiology, School of Medicine in Katowice, Medical University of Silesia, Katowice, Poland.
Role of Genetic Testing in Diagnosis and Prognosis Prediction in Hypertrophic Cardiomyopathy in Korea.
J Korean Med Sci
December 2024
Division of Cardiology, Severance Cardiovascular Hospital, Yonsei University College of Medicine, Seoul, Korea.
Background: Hypertrophic cardiomyopathy (HCM) needs careful differentiation from other cardiomyopathies. Current guidelines recommend genetic testing, but genetic data on differential diagnoses and their relation with clinical outcomes in HCM are still lacking. This study aimed to investigate the prevalence of genetic variants and the proportion of other cardiomyopathies in patients with suspected HCM in Korea and compare the outcomes of HCM according to the presence of sarcomere gene mutation.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!