AI Article Synopsis
- - A treat-to-target (T2T) approach focuses on setting specific therapeutic goals for disease management, requiring regular check-ins and treatment adjustments to improve patient outcomes.
- - Implementing T2T in Antiphospholipid Syndrome (APS) is challenging due to the disease's diverse symptoms and the absence of reliable markers to measure disease activity.
- - Despite these difficulties, T2T strategies remain crucial for APS management, aiming to control the disease better, minimize recurrence risks, and improve patients' overall quality of life.
Article Abstract
A treat-to-target (T2T) approach aims to the identification of a clinically relevant therapeutic target and applies tight control (periodic visits at prespecified time-points and treatment adjustments) to achieve it with the goal of improving disease outcomes. The application of a T2T strategy appears to be less feasible in APS compared to other autoimmune diseases. This is primarily explicable by the disease's kaleidoscopic clinical presentation, along with the lack of a definitive tool (biomarkers or scoring system) to assess disease activity, making it complex to recognize a singular, effective therapeutic target for APS patients. Nevertheless, the conceptualization of T2T strategies should be considered a key objective when managing APS, aiming to achieve optimal disease control (including lowering the risk for recurrences), to reduce damage accumulation, and, ultimately, to enhance patients' quality of life.
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| http://dx.doi.org/10.1016/j.autrev.2024.103690 | DOI Listing |
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