AI Article Synopsis
- Advances in molecular and spatial profiling techniques, along with AI/ML, are enhancing the construction and integration of cell atlases, like the Human Cell Atlas.
- Cell atlases offer valuable insights, serving as censuses of cells, 3D maps showing cell distributions in the body, and connections between genetic causes and observable traits.
- They are evolving into comprehensive 4D developmental maps and foundational models of biology, with the potential to significantly impact the field of medicine.
Article Abstract
With the convergence in exciting advances in molecular and spatial profiling methods and new computational approaches leveraging artificial intelligence and machine learning (AI/ML), the construction of cell atlases is progressing from data collection to atlas integration and beyond. Here, we explore five ways in which cell atlases, including the Human Cell Atlas, are already revealing valuable biological insights, and how they are poised to provide even greater benefits in the coming years. In particular, we discuss cell atlases as censuses of cells; as 3D maps of cells in the body, across modalities and scales; as maps connecting genotype causes to phenotype effects; as 4D maps of development; and, ultimately, as foundation models of biology unifying all these aspects and helping to transform medicine.
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| http://dx.doi.org/10.1038/s41586-024-08338-4 | DOI Listing |
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