Severity: Warning
Message: file_get_contents(https://...@gmail.com&api_key=61f08fa0b96a73de8c900d749fcb997acc09): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests
Filename: helpers/my_audit_helper.php
Line Number: 143
Backtrace:
File: /var/www/html/application/helpers/my_audit_helper.php
Line: 143
Function: file_get_contents
File: /var/www/html/application/helpers/my_audit_helper.php
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Function: simplexml_load_file_from_url
File: /var/www/html/application/helpers/my_audit_helper.php
Line: 3098
Function: getPubMedXML
File: /var/www/html/application/controllers/Detail.php
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Function: pubMedSearch_Global
File: /var/www/html/application/controllers/Detail.php
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Function: pubMedGetRelatedKeyword
File: /var/www/html/index.php
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Function: require_once
Severity: Warning
Message: Attempt to read property "Count" on bool
Filename: helpers/my_audit_helper.php
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File: /var/www/html/application/helpers/my_audit_helper.php
Line: 3100
Function: _error_handler
File: /var/www/html/application/controllers/Detail.php
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Function: pubMedSearch_Global
File: /var/www/html/application/controllers/Detail.php
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Function: pubMedGetRelatedKeyword
File: /var/www/html/index.php
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Function: require_once
Estimating effective reproduction number (R) and predicting disease incidences are essential to formulate effective strategies for disease control. Although recent studies developed models for inferring R from wastewater-based data, they require information on shedding dynamics. Here, we proposed a framework of R estimation and prediction without shedding information. The framework consists of a space-state model for smoothing wastewater-based data and a renewal equation modified for wastewater-based data. The applicability of the framework was tested with simulated data and real-world data on Influenza A virus (IAV) and SARS-CoV-2 concentration in wastewater in 2022/2023 season in the USA. We confirmed the state-space model effectively fits various simulated epidemic curves and real-world data. In simulations, we found wastewater-based R (R) closely aligns with instantaneous clinical R when shedding dynamics are rapid. For more prolonged shedding, R approximates a smoothed R over time. We also observed the necessary sampling frequency to trace dynamics of wastewater concentration and R accurately in the framework varies depending on the precision of detection methods, the epidemic status, the transmissibility of infectious diseases, and shedding dynamics. By applying our framework to real-world data, we found R for SARS-CoV-2 showed similar trend and values to clinically-based R. R for IAV ranged from 0.66 to 1.52 with a clear peak in the winter season, which agrees with previously reported R. We also succeeded in predicting wastewater concentration in a few weeks from available wastewater-based data. These results indicate that our framework potentially enables near real-time monitoring of approximated R and prediction of infectious disease dynamics through wastewater surveillance, which limits the delay between infection and reporting. Our framework is useful especially for regions where reliable clinical surveillance is not available and notifiable surveillance is abolished, and can be expanded to multiple infectious diseases that have been detected from wastewater.
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Source |
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http://dx.doi.org/10.1016/j.envint.2024.109128 | DOI Listing |
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