Talarindigotin A: a cytotoxic indigotin derivative, from the mangrove endophytic fungus SCNU-F0041.

J Asian Nat Prod Res

School of Chemistry, Guangzhou Key Laboratory of Analytical Chemistry for Biomedicine, South China Normal University, Guangzhou 510006, China.

Published: November 2024

A new indigotin alkaloid, named talarindigotin A (), along with the analogue 5H, 6H-quinindolin-11-one () were isolated from the mangrove endophytic fungus SCNU-F0041. Their structures were assigned on the basis of NMR, HRMS, and single-crystal X-ray diffraction analysis. In the cytotoxic bioassay, compound showed great cytotoxicity against HepG2, Hela, HCT116, and Huh7 human cancer cell lines with IC values ranging from 2.08 to 4.58 μM.

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Source
http://dx.doi.org/10.1080/10286020.2024.2428228DOI Listing

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