AI Article Synopsis
- Four lactic acid bacteria (LAB) strains were tested for their ability to survive harsh intestinal conditions and adhere to intestinal cells, with Lactobacillus brevis 505 showing the best performance.
- After treatment with ciprofloxacin, mice experienced some recovery in their intestinal flora naturally, but full restoration was difficult; however, intervention with L. brevis 505 resulted in significantly better recovery of intestinal health compared to natural recovery.
- L. brevis 505 not only helped improve the diversity and abundance of beneficial gut bacteria but also regulated immune factors, making it a promising probiotic for restoring gut microbiota after antibiotic treatment.
Article Abstract
In this study, four lactic acid bacteria (LAB) strains demonstrating ciprofloxacin, bile salt, gastric fluid, and intestinal fluid tolerance as well as adhesion ability to Caco-2 and HT-29 cells were used to improve and recover the intestinal flora disorders caused by ciprofloxacin, among which, Lactobacillus brevis 505 exhibited excellent adhesion ability to two kinds of cells and colonization ability to mouse intestinal. After ciprofloxacin treatment, certain recovery effect on cecum caused by ciprofloxacin in the mice was found during natural recovery (group 5C2), but it was challenging to fully restore the intestinal integrity to the initial level. After L. brevis 505 intervention (group 5C5), the intestinal damage to the colon and ileum caused by ciprofloxacin in mice was significantly alleviated; the recovery effect was better than that of natural recovery. Additionally, L. brevis 505 could effectively regulate INF-γ, sIgA, and RegIIIγ increase induced by ciprofloxacin. Shannon and Simpson index of the intestinal flora of mice in 5C5 group were higher than those in other group, the relative abundance of Bifidobacterium and Lactobacillus in the mice in 5C5 group was increased, indicating that LAB can better restore the structure and abundance of intestinal microflora. Consequently, L. brevis 505 shows promise as a probiotic for gut microbiota restoration and rebuilding during antibiotic therapy.
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| http://dx.doi.org/10.1007/s12602-024-10401-5 | DOI Listing |
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