Prospective memory (PM) impairment is a common consequence of moderate-severe traumatic brain injury (TBI). Compensatory strategy training and rehabilitation (COMP) is the usual treatment of PM deficits through environmental modification and the use of assistive methods such as diaries and routines. The study intends to examine the changes in white matter integrity, as measured by advanced diffusion magnetic resonance imaging (dMRI) following COMP intervention in moderate-severe TBI patients. Nine COMP intervention and twelve routine care comparison cohort moderate-severe TBI patients were recruited from level 1 trauma centres in the Brisbane metropolitan area. Both groups were imaged at least one-month post-TBI for a baseline scan. COMP group was imaged again after a 6-week COMP intervention program and the comparison group was imaged again at least 6 weeks after the baseline scan. MRI scan included structural imaging and dMRI, which the latter fitted for the Neurite Orientation Dispersion and Density Imaging (NODDI) model. Only the comparison group had decreased Neurite Density Index in the major white matter tracts and increased isotropic diffusion in the fluid space between the cortical folds. Our results indicated that COMP intervention slowed down the neural degeneration in moderate-severe TBI patients as compared to routine medical care/rehabilitation.
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http://dx.doi.org/10.1080/09602011.2024.2423861 | DOI Listing |
Int J Biol Macromol
December 2024
Grupo de Materiales Compuestos Termoplásticos (COMP), Instituto de ciencia y tecnología de Materiales (INTEMA), Universidad Nacional de Mar del Plata (UNMdP) y Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Av. Colón 10890, 7600 Mar del Plata, Buenos Aires, Argentina.
Gelatin and chondroitin sulfate are natural polymers with significant potential in the biomedical field, particularly for wound healing applications. They can form hydrogels that absorb exudates and exhibit anti-inflammatory and antioxidant properties. Silver nanoparticles (AgNPs) can be used as antibacterial agents in wound management.
View Article and Find Full Text PDFMod Rheumatol
December 2024
Menzies Institute for Medical Research, University of Tasmania, Hobart, Australia.
Objectives: To describe the associations between OA-related biochemical markers and knee symptoms in middle-aged adults followed up over 10-13 years.
Methods: Blood samples were collected during the Childhood Determinants of Adult Health (CDAH)-1 study (year: 2004-06) and 10-13 year follow-up at CDAH-3. Serum samples from baseline (n=156) and follow-up (n=167) were analyzed for three OA-related biomarkers [cartilage oligomeric matrix protein (COMP), matrix metalloproteinase (MMP)-3, and hyaluronan (HA)] using non-isotopic enzyme-linked immunosorbent assay (ELISA).
Am J Physiol Regul Integr Comp Physiol
December 2024
School of Integrative Physiology and Athletic Training, Montana Center for Work Physiology and Exercise Metabolism, University of Montana, Missoula, MT, USA.
Nocturnal oxygen enrichment improves sleep at high-altitude but may impair acclimatization. Determine if nocturnal oxygen enrichment impacts acclimatization. A 7-day acclimatization protocol occurred at a field-based research site between 0-4200m.
View Article and Find Full Text PDFJ Comp Neurol
December 2024
Wilkes Honors College, Florida Atlantic University, Jupiter, Florida, USA.
Neurons rely on mitochondria for an efficient supply of ATP and other metabolites. However, while neurons are highly elongated, mitochondria are discrete and limited in number. Due to the slow rates of metabolite diffusion over long distances, it follows that neurons would benefit from an ability to control the distribution of mitochondria to sites of high metabolic activity such as synapses.
View Article and Find Full Text PDFJ Minim Invasive Gynecol
December 2024
Section of Female Pelvic Medicine and Reconstructive Surgery, Department of Obstetrics and Gynecology, Georgetown University School of Medicine, Washington, DC, USA. Electronic address:
Study Objective: The primary objective of this study was to describe vaginal hysterectomy practice patterns as well as facilitators and inhibitors to performing vaginal hysterectomy among gynecologic surgeons. Secondary objectives were to describe facilitators and inhibitors to the teaching and training of vaginal hysterectomy.
Design: Quantitative analysis of an online survey and qualitative analyses of the one-on-one interviews on gynecologic surgeons was conducted.
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