We developed a water-promoted cross-coupling of 3-hydroxyisobenzofuran-1(3)-ones and allylic boronates under biocompatible conditions. This approach facilitates the synthesis of diverse 3-allylic phthalides with high yields and exceptional selectivity in a metal-free manner. The versatility and practicality of this protocol underscore its significant potential for drug development and applications in medicinal chemistry.
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| http://dx.doi.org/10.1021/acs.orglett.4c04189 | DOI Listing |
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