Background: The Trail Making Test (TMT) is a famous neuropsychological test that is frequently used. The structure of a paper-and-pencil-based TMT is highly likely to be adapted to a mobile app.
Objective: The current study aimed to develop and validate an Android-based tablet version of TMT.
Methods: The application (TMT App) was developed using an Android-based platform. Healthy and depressed individuals ( = 133) were assessed on both the TMT versions (paper-based version and app-based version) in a random cross-over design. The device's usability was ascertained using the system usability scale (SUS) in a subset of individuals ( = 65).
Results: There was a significant positive correlation between the individual processing times for the paper-based TMT-A and the app-based TMT-A in both healthy and depression groups [r(63) = 0.55, < .001; and r(66) = 0.77, < .001, respectively]. The individual processing times of the paper-based TMT-B and the app-based TMT-B also showed a significant positive correlation in both healthy control and depression groups [r(63) = 0.67, < .001; and r(66) = 0.89, < .001, respectively]. There was a positive correlation of age with TMT-A and TMT-B for either version. Both groups had similar positive responses to the usability of the TMT App.
Conclusion: The preliminary validation results for the TMT App suggest that it is significantly correlated with existing paper-and-pencil methods, and that it is user friendly.
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http://dx.doi.org/10.1177/02537176241247789 | DOI Listing |
J Prev Alzheimers Dis
January 2025
Université Paris Cité, INSERM U1153, Centre of Research in Epidemiology and Statistics, Team Epidemiology of Ageing and Neurodegenerative Diseases, 10 avenue de Verdun, 75010 Paris, France; Faculty of Brain Sciences, University College London, 38-50 Bidborough Street, WC1H 9BT London, UK.
Background And Objectives: Primary care is often the first point of contact for patients with cognitive complaints, making initial cognitive screening an essential step to avoid delays in diagnosing Alzheimer's disease (AD) at an early stage. We developed MemScreen, a self-administered smartphone application that assesses overall cognition and verbal memory, and evaluated its ability to detect mild cognitive impairment (MCI) in both general and clinical populations.
Methods: We conducted two validation cohort studies: (1) UK-based Whitehall II cohort study (13th wave, 2018-2022) involving a general population (MCI defined by poor performance on a global cognitive score), and (2) five French memory clinics involving patients without dementia (amnestic MCI defined by the Free and Cued Selective Reminding Test).
Indian J Psychol Med
May 2024
Brain Mapping Lab, Dept. of Psychiatry, All India Institute of Medical Sciences, New Delhi, India.
Food Funct
November 2024
Department of Clinical Nutrition, Shenzhen Longgang Central Hospital, Shenzhen 518116, China.
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by progressive behavioral and cognitive impairments. Despite growing evidence of the neuroprotective action of omega-3 polyunsaturated fatty acids (PUFAs), the effects and mechanism of omega-3 PUFAs on AD control are yet to be clarified. By crossing male heterozygous fat-1 mice with female APP/PS1 mice, we assessed whether elevated tissue omega-3 PUFA levels could alleviate AD progression and their underlying mechanism among the offspring WT, APP/PS1 and APP/PS1 × fat-1 groups at various stages.
View Article and Find Full Text PDFFront Aging Neurosci
September 2024
Department of Nephrology, Beijing Shijitan Hospital, Capital Medical University, Beijing, China.
Background: The mechanism of cognitive impairment in hemodialysis patients is multifactorial. The relationship between cerebral blood flow and the decline of cognitive function is poorly understood.
Objective: To investigate the association between cerebral blood flow variation and decline of cognitive function in older patients undergoing hemodialysis.
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