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| http://dx.doi.org/10.3389/fgene.2024.1512594 | DOI Listing |
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Hospital-level volume in extracorporeal membrane oxygenation cases and death or disability at 6 months.
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Australian and New Zealand Intensive Care Research Centre, Monash University, Melbourne, Australia.
Objective: Extracorporeal membrane oxygenation (ECMO) is a high-risk procedure with significant morbidity and mortality and there is an uncertain volume-outcome relationship, especially regarding long-term functional outcomes. The aim of this study was to examine the association between ECMO centre volume and long-term death and disability outcomes.
Design Setting And Participants: This is a registry-embedded observational cohort study.
Acute kidney injury following CAR-T cell therapy: a nephrologist's perspective.
Clin Kidney J
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Department of Medicine, Universidad Autonoma de Madrid and IIS-Fundacion Jimenez Diaz, Madrid, Spain.
Chimeric antigen receptor T (CAR-T) cell therapy, an emerging personalized immunotherapy for various haematologic malignancies, autoimmune diseases and other conditions, involves the modification of patients' T cells to express a chimeric antigen receptor that recognizes tumour or autoimmune cell antigens, allowing CAR-T cells to destroy cancerous and other target cells selectively. Despite remarkable clinical improvements in patients, multiple adverse effects have been associated with CAR-T cell therapy. Among the most recognized adverse effects are cytokine release syndrome, immune effector cell-associated neurotoxicity syndrome and tumour lysis syndrome.
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Showa General Hospital, Kodaira-Shi, Tokyo, 187-8510, Japan.
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View Article and Find Full Text PDFAre Animal Models Necessary? Exploring (Dis)advantages and Alternatives.
Eur J Neurosci
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Pharmacology and Neurobiology Laboratory of the Immunophysiology and Pharmacology Department, School of Medicine and Biomedical Sciences (ICBAS), University of Porto, Porto, Portugal.
Animal models have been crucial for scientific development, allowing researchers to understand the underlying mechanisms of various human conditions, and are far from becoming obsolete in scientific research. However, the ethics of animal experimentation has been a prevalent question between both experts and nonexperts. This essay tackles the advantages and disadvantages of the usage of animal models while delving into new alternatives that have emerged in light of contemporary science.
View Article and Find Full Text PDFAn evaluation of parents' and caregivers' preferences managing fever in children based on experiences in using ibuprofen and paracetamol: A systematic review.
J Pediatr Nurs
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University of Newcastle, Australia; Centre for Transformative Nursing, Midwifery, and Health Research: A JBI Centre of Excellence, Australia.
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