This review is devoted to specific features of diagnosis and treatment of non-gonococcal urethritis caused by intracellular microorganisms. Using modern literature data and the up-to-date clinical guidelines, an analysis of changes in the epidemiological structure and resistance of intracellular pathogens in non-gonococcal urethritis has been carried out. The current principles of diagnosis and treatment of non-gonococcal urethritis are reviewed, with a discussion of the place of new molecular genetic methods for detecting the resistance of some intracellular pathogens (Mycoplasma genitalium) in routine clinical practice. Treatment regimens proposed by various clinical guidelines are compared and critically appraised in the review. Both clinical data and the results of in vitro studies on the efficiency of various drugs against certain intracellular pathogens of urethritis are presented.
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BMC Infect Dis
December 2024
Melbourne Sexual Health Centre, Alfred Health, 580 Swanston Street, Carlton, Melbourne, VIC, 3053, Australia.
Background: A significant proportion of individuals with symptoms of sexually transmitted infection (STI) delay or avoid seeking healthcare, and digital diagnostic tools may prompt them to seek healthcare earlier. Unfortunately, none of the currently available tools fully mimic clinical assessment or cover a wide range of STIs.
Methods: We prospectively invited attendees presenting with STI-related symptoms at Melbourne Sexual Health Centre to answer gender-specific questionnaires covering the symptoms of 12 common STIs using a computer-assisted self-interviewing system between 2015 and 2018.
Arch Microbiol
November 2024
Institute of Pathogenic Biology, Basic Medical School, Hengyang Medical School, University of South China, Hengyang Central Hospital, Hengyang, 421001, China.
Mycoplasma genitalium, Ureaplasma urealyticum and Mycoplasma hominis are bacterial pathogens found in the genitourinary tract, implicated in a range of infections. In women, these infections including pelvic inflammatory disease, vaginitis, infertility, and cervical cancer, while in men, they can cause non-gonococcal urethritis, prostate cancer, among other conditions. These infections are a global health concern, with China identified as a country with a high prevalence.
View Article and Find Full Text PDFThis review is devoted to specific features of diagnosis and treatment of non-gonococcal urethritis caused by intracellular microorganisms. Using modern literature data and the up-to-date clinical guidelines, an analysis of changes in the epidemiological structure and resistance of intracellular pathogens in non-gonococcal urethritis has been carried out. The current principles of diagnosis and treatment of non-gonococcal urethritis are reviewed, with a discussion of the place of new molecular genetic methods for detecting the resistance of some intracellular pathogens (Mycoplasma genitalium) in routine clinical practice.
View Article and Find Full Text PDFCureus
September 2024
Infectious Diseases Department, Unidade Local de Saúde Gaia e Espinho, Vila Nova De Gaia, PRT.
BMC Infect Dis
September 2024
Naval Medical Research EURAFCENT, Ghana Detachment, Noguchi Memorial Institute for Medical Research (NMIMR), P.O. Box LG581, Legon, Accra, Ghana.
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