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Mechanisms of Vitamins Inhibiting Ferroptosis.
Antioxidants (Basel)
December 2024
College of Veterinary Medicine, Yangzhou University, Yangzhou 225009, China.
Ferroptosis is an iron-dependent form of cell death, which is characterized by the uncontrolled and overwhelming peroxidation of cell membrane lipids. Ferroptosis has been implicated in the progression of various pathologies, including steatotic liver, heart failure, neurodegenerative diseases, and diabetes. Targeted inhibition of ferroptosis provides a promising strategy to treat ferroptosis-related diseases.
View Article and Find Full Text PDFTemperature and Ultrasound-Responsive Nanoassemblies for Enhanced Organ Targeting and Reduced Cardiac Toxicity.
Int J Nanomedicine
November 2024
Department of Cardiothoracic Surgery, Huashan Hospital of Fudan University, Shanghai, People's Republic of China.
Background: Biocompatible nanocarriers are widely employed as drug-delivery vehicles for treatment. Nevertheless, indiscriminate drug release, insufficient organ-specific targeting, and systemic toxicity hamper nanocarrier effectiveness. Stimuli-responsive nano-sized drug delivery systems (DDS) are an important strategy for enhancing drug delivery efficiency and reducing unexpected drug release.
View Article and Find Full Text PDFFe-based metal-organic frameworks modified with carboxymethyl cellulose for targeted pesticide delivery and reducing biotoxicity.
Int J Biol Macromol
December 2024
College of Plant Protection, Yangzhou University, Yangzhou 225009, China.
Traditional pesticide formulations have issues such as poor targeting, low adhesion performance, and a tendency to leach into the environment, causing pollution. In this study, a pesticide delivery platform (PRO@FeMOFs@CMC) with a dual response was designed by encapsulating prochloraz technical (PRO) within Fe-based metal-organic frameworks (FeMOFs) and using carboxymethyl cellulose (CMC) as the gatekeeper. The results showed that PRO@FeMOFs@CMC exhibited a loading capacity of 28.
View Article and Find Full Text PDFIdentification of a divalent metal transporter required for cellular iron metabolism in malaria parasites.
Proc Natl Acad Sci U S A
November 2024
Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, UT 84112.
malaria parasites invade and multiply inside red blood cells (RBCs), the most iron-rich compartment in humans. Like all cells, requires nutritional iron to support essential metabolic pathways, but the critical mechanisms of iron acquisition and trafficking during RBC infection have remained obscure. Parasites internalize and liberate massive amounts of heme during large-scale digestion of RBC hemoglobin within an acidic food vacuole (FV) but lack a heme oxygenase to release porphyrin-bound iron.
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