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Process and validity of linking cystic fibrosis patient registry with national Medicaid databases.

J Cyst Fibros

November 2024

Rutgers University Institute for Health, Health Care Policy and Aging Research, New Brunswick, New Jersey, USA; Department of Medicine, Rutgers Robert Wood Johnson Medical School, Piscataway, New Jersey, USA; Department of Biostatistics and Epidemiology, Rutgers School of Public Health, Piscataway, New Jersey, USA. Electronic address:

Article Synopsis
  • * A matching algorithm was used to connect 10,616 individuals with CF from CFFPR to Medicaid data, revealing that those linked had significantly higher outpatient visits and antibiotic prescriptions than reported in the CFFPR alone.
  • * The study found high costs associated with CF treatment in North Carolina, with pharmacy costs reaching $16.4 million and non-pharmacy costs totaling $7.5 million, highlighting the potential for comprehensive analysis of healthcare utilization and costs for low-income CF patients through linked data.
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A near-infrared fluorescent probe, , was designed by substituting the carbonyl group of the coumarin dye's lactone with a 4-cyano-1-methylpyridinium methylene group and then attaching an electron-withdrawing NADH-sensing methylquinolinium acceptor via a vinyl bond linkage to the coumarin dye at the 4-position. The probe exhibits primary absorption maxima at 603, 428, and 361 nm, and fluoresces weakly at 703 nm. The addition of NAD(P)H results in a significant blue shift in the fluorescence peak from 703 to 670 nm, accompanied by a substantial increase in fluorescence intensity.

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Inhalation exposure to chemicals, microbiota dysbiosis and adverse effects on humans.

Sci Total Environ

December 2024

School of Life Sciences and Allied Health Professions, Kamuzu University of Health Sciences, Blantyre Campus, Mahatma Gandhi Road, Blantyre 312224, Malawi.

Article Synopsis
  • Disruption of the lung microbiota (LM) can mediate harmful effects from inhaled chemicals, influencing respiratory health and linked to conditions like asthma and lung cancer.
  • Factors such as air pollution and cigarette smoke can cause LM dysbiosis, affecting the gut microbiota and potentially leading to diseases through interactions like the Gut-Lung axis.
  • More rigorous research is needed to establish causal links between LM dysbiosis and respiratory diseases, as current findings are primarily associative, and advancing techniques for studying the lung microbiome can improve understanding of these connections.
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Background: The Cystic Fibrosis Foundation Patient Registry (CFFPR) maintains clinical data, including history of solid organ transplant, on people with cystic fibrosis (CF) who obtain care at CF Foundation-accredited care centers. The Scientific Registry of Transplant Recipients (SRTR) database is a collection of national data related to organ transplantation that supports research to evaluate solid organ transplant candidate and recipient outcomes.

Methods: Individuals in the CFFPR were matched to SRTR records using an algorithm that compared names, last four digits of social security numbers, date of birth and date of death.

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Advances in COPD imaging using CT and MRI: linkage with lung physiology and clinical outcomes.

Eur Respir J

May 2024

Division of Infection, Immunity and Respiratory Medicine, The University of Manchester and Manchester University NHS Foundation Trust, Manchester Academic Health Sciences Centre, Manchester, UK.

Article Synopsis
  • * Magnetic resonance imaging (MRI) has emerged as a valuable tool for assessing both structural and functional lung issues without radiation, particularly beneficial for early detection in smokers and COPD patients.
  • * These imaging techniques allow for comprehensive evaluations of lung structure and function, helping to better understand disease patterns and guide treatment decisions.
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