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http://dx.doi.org/10.1007/s00277-024-06095-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11695442PMC

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Article Synopsis
  • The study investigates DNA methylation patterns of specific solute carrier genes linked to epilepsy in patients with temporal lobe epilepsy (TLE) and healthy controls.
  • Results show that TLE patients have significantly lower DNA methylation rates compared to controls, which may help in developing predictive models for TLE.
  • The findings indicate that reduced methylation could potentially lead to increased gene expression in TLE, but further research is needed to clarify the mechanisms involved.
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ROS promote hyper-methylation of NDRG2 promoters in a DNMTS-dependent manner: Contributes to the progression of renal fibrosis.

Redox Biol

June 2023

Department of Nephrology, Shandong Provincial Hospital, Shandong University, Jinan, Shandong, 250021, China. Electronic address:

Renal fibrosis is the common histopathological feature of chronic kidney diseases (CKD), and there is increasing evidence that epigenetic regulation is involved in the occurrence and progression of renal fibrosis. N-myc downstream-regulated gene 2 (NDRG2) is significantly down-regulated in renal fibrosis, the mechanism of which remains unclear. Previous studies have confirmed that the inhibition of NDRG2 expression in tumor cells is related to hyper-methylation, mainly regulated by DNA methyltransferases (DNMTS).

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