AI Article Synopsis
- Spinal muscular atrophy (SMA2) is a severe neuromuscular disorder that can lead to spinal deformities like scoliosis, often requiring early surgical intervention when bracing is ineffective.
- The study investigated changes in spinal and thigh muscles in SMA2 patients before and after a minimally invasive spinal surgery, involving MRI analysis for fat infiltration in muscle tissues.
- Results showed increased fat infiltration in certain muscles post-surgery, but overall muscle involvement was significant in both preoperative and postoperative groups, while quality of life remained unaffected by these changes.
Article Abstract
Background: Spinal muscular atrophy is a severe, progressive autosomal recessive neuromuscular disorder associated with neuromuscular scoliosis. When bracing is not sufficient to control the deformity, early spinal surgery is required. To the best of our knowledge, no work in the literature have assessed modifications in spinal and thigh muscles of subjects with type 2 spinal muscular atrophy (SMA2) following spinal surgery.
Objective: This study aimed to better understand modifications in the spinal and thigh muscles of subjects with SMA2 and early onset scoliosis, before and after minimally invasive fusionless surgery.
Methods And Settings: 20 SMA2 patients with confirmed scoliosis on bi-planar low-dose X-ray were included: 10 preoperative and 10 postoperative patients with a minimal follow-up of 5 years after surgery. The surgery consisted of a bilateral sliding rod construct extended from T1 to the sacrum, through a minimally invasive approach. All subjects had fat/water separation muscle magnetic resonance imaging from the spine to the thigh. The percentage of fat degeneration was compared before and after surgery. A quality-of-life survey was performed.
Results: Fat infiltration was diffuse and symmetric in both groups of patients, and on average six times more compared to control subjects previously published at thigh level. Adductors, sartorius, and gracilis were less affected with respectively, 51%, 56%, and 57% of fat fraction before surgery. Comparing the preoperative and postoperative groups, fat infiltration was higher in sartorius and multifidus after surgery (p < 0.05). No significant difference was found for the other muscles studied. These results did not affect quality of life.
Conclusion: This is the first study to compare fat infiltration of spinal and thigh muscles of SMA2 patients before and after minimally invasive surgery. Our results demonstrate that muscles were globally preserved apart from multifidus and sartorius which were more affected.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.arcped.2024.08.005 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
A Case Study of Intradural Extramedullary Spinal Schwannoma and Mul-tiple Thoracic Vertebral Haemangiomas Following COVID-19 Infection and Vaccination: Insights from MRI Imaging.
Infect Disord Drug Targets
December 2024
Diagnostic Radiography Technology Department, Faculty of Nursing and Health Sciences, Jazan University, Jazan, Saudi Arabia.
Introduction: Spinal schwannomas are benign intradural extramedullary tumors of Schwann cells, while hemangiomas are common benign vascular tumors found in the vertebral column.
Case Representation: This case study presents a 32-year-old male who developed both a spinal schwannoma and multiple thoracic vertebral haemangiomas following a COVID-19 infection and subsequent vaccination. The patient reported intermittent lumbar and thigh pain over 6-8 months.
Severe Transverse Myelitis Following Ankle Surgery Potentially Unmasking Late-Onset Systemic Lupus Erythematosus.
Cureus
November 2024
Internal Medicine, ECU Health, Greenville, USA.
A 70-year-old female underwent open reduction and internal fixation (ORIF) of her right ankle following a mechanical trip and fell two weeks before hospital admission. Two weeks following surgery, the patient experienced sudden-onset bilateral anterior thigh paresthesias and burning mid-back pain. Over the ensuing two days, the patient developed bilateral lower extremity weakness, bilateral lower extremity numbness, and urinary retention with constipation, which led to hospital presentation.
View Article and Find Full Text PDFDynamic Alignment Changes of the Spine, Pelvis, and Lower Limbs during Gait Analyzed Using Inertial Motion Capture in Patients with Adult Spinal Deformity.
Spine Surg Relat Res
November 2024
Department of Orthopaedic Surgery, Dokkyo Medical University, Mibu, Japan.
Introduction: Patients with adult spinal deformity (ASD) lean forward with their trunks when walking, even if they can remain upright during static standing. However, it remains unclear which part of the spinal column is involved in forward trunk tilt and the details of the relationships between sagittal alignment during static standing and changes in dynamic parameters during walking. Therefore, this study aimed to clarify the above by analyzing the walking motion of ASD patients using inertial measurement units (IMUs).
View Article and Find Full Text PDFEfficacy of Blood Flow Restriction Exercise for Improving Lower Limb Muscle Strength and Function in Chronic Spinal Cord Injury: A Randomized Controlled Trial.
Scand J Med Sci Sports
December 2024
Spinal Cord Injury Centre of Western Denmark, Hammel Neurorehabilitation Centre and University Research Clinic, Viborg, Denmark.
The objective of the present study was to evaluate the efficacy of low-load (LL) blood flow restriction exercise (BFRE) for improving lower limb muscle strength, muscle thickness and physical function in individuals with spinal cord injury (SCI). In a randomized sham-controlled trial, 21 participants (age ≥ 18 years, SCI duration ≥ 1 year, knee extensor strength grade 2-4, ASIA A-D) were randomized to either 45-min LL-BFRE (n = 11) or sham BFRE (n = 10) twice/week for 8 weeks. The exercise protocol consisted of four sets (30 × 15 × 15 × 15 repetitions) of unilateral seated leg extensions and leg curls at 30%-40% of 1RM performed with pneumatic cuffs applied proximally on the trained limb and inflated to 40% of total arterial occlusion pressure (BFRE) or non-inflated (sham exercise).
View Article and Find Full Text PDFLongitudinal Quantitative MRI Provides Responsive Outcome Measures for Early and Late Muscle Changes in ALS.
Muscle Nerve
February 2025
Board of Governors Regenerative Medicine Institute, Cedars-Siniai Medical Center, Los Angeles, California, USA.
Introduction/aims: Studies have demonstrated the potential of muscle MRIs to measure disease progression in ALS. However, the responsiveness and utility of quantitative muscle MRIs in an ALS clinical trial remain unknown. This study aimed to determine the responsiveness of quantitative muscle MRIs to measure disease progression in ALS.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!