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Comparison of the CT-based micromotion analysis method versus marker-based RSA in measuring femoral head translation and evaluation of its intra- and interobserver reliability: a prospective agreement diagnostic study on 27 patients up to 1 year.
Acta Orthop
January 2025
Department of Orthopaedics, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg; Department of Orthopaedics, Sahlgrenska University Hospital, Region Västra Götaland, Gothenburg, Sweden.
Background And Purpose: Computed tomography radiostereometric analysis (CT-RSA) assesses implant micromovements using low-dose CT scans. We aimed to investigate whether CT-RSA is comparable to marker-based radiostereometric analysis (RSA) measuring early femoral head migration in cemented stems. We hypothesized that CT-RSA is comparable to marker-based RSA in evaluating femoral head subsidence.
View Article and Find Full Text PDFBackground: Studies suggest that structural changes in the midbrain are linked to Alzheimer's disease (AD) symptoms such as memory, sleep, and emotional disturbances. Brainstem atrophy, particularly in the locus coeruleus, has also been linked with poorer executive function. Studies showing brainstem as one of the first regions affected by AD largely employed novel imaging techniques such as neuromelanin-sensitive MRI, which is limited to research environments.
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Alzheimers Dement
December 2024
Columbia University Irving Medical Center, New York, NY, USA.
Background: Alzheimer's disease (AD) health literacy is low in high-risk populations and is likely a determinant of timely care seeking behavior. Our group aimed to develop a novel brief questionnaire for use in community outreach and related studies of AD awareness.
Methods: We developed an initial 15-item AD knowledge questionnaire "ASK-AD (Assess Symptoms and Knowledge of AD)" following pilot study and cognitive interviews with subject matter experts along with elementary school children.
Biomarkers.
Alzheimers Dement
December 2024
Centre for Brain Research, Indian Institute of Science, Bangalore, Karnataka, India.
Background: Though frailty is common in aging, its impact on varied health outcomes has been grossly understudied among rural Indians. We aimed to cross-sectionally examine the impact of physical frailty on 13 health outcomes and brain structure in this population.
Method: Participants (n=5302) were non-demented, aging individuals (≥45 years) from the ongoing Srinivaspura Aging Neuro Senescence and Cognition (SANSCOG) cohort in rural southern India.
Biomarkers.
Alzheimers Dement
December 2024
Wake Forest University School of Medicine, Winston-Salem, NC, USA.
Background: Cardiometabolic disorders are emerging risk factors for Alzheimer's disease (AD) and AD-related dementia (ADRD). There is currently insufficient understanding of how different cardiometabolic profiles and blood biomarkers impact different AD-related brain pathology regionally. This project uses data-driven approaches and explainable artificial intelligence methods to determine the cardiometabolic and fluid contributions toward AD-related pathophysiologic patterns in the brain.
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