AI Article Synopsis
- A study was conducted to assess the effectiveness of using porcine anterior lens capsules as a substitute for Bowman layer grafts in rabbits with keratoconus, due to a shortage of donor corneas.
- The research involved transplanting the lens capsules into the corneal stroma of rabbits and monitoring changes in corneal transparency, thickness, and shape at various time points.
- Results indicated that the transplanted lens capsules preserved corneal transparency and structural integrity without any negative effects, suggesting they could be viable alternatives to Bowman layer grafts in corneal surgeries.
Article Abstract
Purpose: The shortage of donor corneas limits Bowman layer transplantation for keratoconus. In this study, we evaluate the clinical outcome of porcine anterior lens capsule (xenograft) transplantation in the corneal stroma of a rabbit model as substitute for Bowman layer graft that is used in stromal transplantation for advanced keratoconus.
Methods: Transplantation of porcine anterior lens capsule in the corneal stroma was performed in four New Zealand white rabbits through the creation of a stromal pocket. Corneal transparency, central corneal thickness, and topographic characteristics of corneas were evaluated at different time points: pre- (0) and post- (7, 14, 21, and 28) operative days. Additionally, at the end of the study histopathological findings were evaluated.
Results: In comparison to pre-operative day, transplantation of an anterior lens capsule preserved corneal transparency, central corneal thickness, and topographic characteristics remained constant throughout the study period. Histopathological analysis revealed the presence of the anterior lens capsule as a fully integrated lamellar graft without adverse effects in host stroma.
Conclusion: The anterior lens capsule may be useful as a graft for intrastromal corneal trasplantation. Similarly to Bowman layer, anterior lens capsule has mechanical characteristics that facilitate corneal transplantation. In post-transplanted corneas the preservation of transparency, as well as the effect on corneal thickness, and topographic characteristics support the possibility of using anterior lens capsule as a substitute for Bowman layer graft.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11575790 | PMC |
| http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0306015 | PLOS |
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