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Sex Affects Cognitive Outcomes in HIV-1 Tat Transgenic Mice: Role of CCR5.
ASN Neuro
January 2025
Department of Anatomy and Neurobiology, Virginia Commonwealth University, Richmond, Virginia, USA.
People living with HIV (PLWH) experience HIV-associated neurocognitive disorders (HAND), even though combination antiretroviral therapy (cART) suppresses HIV replication. HIV-1 transactivator of transcription (HIV-1 Tat) contributes to the development of HAND through neuroinflammatory and neurotoxic mechanisms. C-C chemokine 5 receptor (CCR5) is important in immune cell targeting and is a co-receptor for HIV viral entry into CD4+ cells.
View Article and Find Full Text PDFThe mediating role of core self-evaluation in the association between perceived peer relationship quality and loneliness in university students.
PLoS One
January 2025
School of Educational Science, Shaoguan University, Shaoguan, Guangdong, China.
This study investigated the mediating role of core self-evaluation (CSE) in the relationship between the perception of peer relationship quality and loneliness among university students during the COVID-19 pandemic. An online survey was conducted with 462 university students (mean age: 20.7 ± 1.
View Article and Find Full Text PDFCoping strategies and changes in type D personality were associated with depressive tendency at 9 months after percutaneous coronary intervention.
PLoS One
January 2025
Division of Nursing, School of Health Sciences, Shinshu University, Matsumoto city, Nagano, Japan.
Type D personality, characterized by negative affectivity and social inhibition, has been associated with both the psychophysiology of coronary artery disease (CAD) and depressive disorders. However, few reports have described the impact of coping strategies in these patients. This study aimed to analyze the characteristics of type D personality and the coping strategies adopted by patients with CAD and to explore the factors associated with depressive tendencies during follow-up.
View Article and Find Full Text PDFAssociation between depression and the prevalence and prognosis of prediabetes: Data from National Health and Nutrition Examination Survey (NHANES) 2013-2018.
PLoS One
January 2025
Department of Pharmacy, NHC Key Laboratory of Hormones and Development, Tianjin Key Laboratory of Metabolic Diseases, Chu Hsien-I Memorial Hospital & Tianjin Institute of Endocrinology, Tianjin Medical University, Tianjin, China.
Background: Diagnosis and intervention of prediabetes is an emerging approach to preventing the progression and complications of diabetes. Inflammatory factors and dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis have been suggested as potential mechanisms underlying the pathogenesis of both diabetes and depression. However, the relationship between depression levels and the prevalence of prediabetes and its prognosis remains elusive.
View Article and Find Full Text PDFSubregions in the ventromedial prefrontal cortex integrate threat and protective information to meta-represent safety.
PLoS Biol
January 2025
Humanities and Social Sciences, California Institute of Technology, Pasadena, California, United States of America.
Pivotal to self-preservation is the ability to identify when we are safe and when we are in danger. Previous studies have focused on safety estimations based on the features of external threats and do not consider how the brain integrates other key factors, including estimates about our ability to protect ourselves. Here, we examine the neural systems underlying the online dynamic encoding of safety.
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