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[The GRAFITI trial: a nationwide prospective clinical trial on active surveillance in patients with non-intraabdominal desmoid-type fibromatosis].
Chirurgie (Heidelb)
December 2024
Chirurgische Klinik, Sarkomzentrum, Universitätsmedizin Mannheim, Medizinische Fakultät Mannheim, Universität Heidelberg, Theodor-Kutzer-Ufer 1-3, 68167, Mannheim, Deutschland.
Health-related Quality of Life of Patients With Non-Intra-abdominal Desmoid-Type Fibromatosis During Active Surveillance: Results of a Prospective Observational Study.
Ann Surg
June 2023
Department of Surgical Oncology, Erasmus MC Cancer Institute Rotterdam, The Netherlands.
Objective: To examine the impact of an active surveillance (AS) approach on the health-related quality of life (HRQoL) of patients with desmoid-type fibromatosis (DTF).
Background Data: AS is recommended as initial approach in DTF patients. AS might however negatively affect HRQoL due to physical symptoms or stress and anxiety.
A Nationwide Prospective Clinical Trial on Active Surveillance in Patients With Non-intraabdominal Desmoid-type Fibromatosis: The GRAFITI Trial.
Ann Surg
April 2023
Department of Surgical Oncology, Erasmus MC Cancer Institute, Rotterdam, The Netherlands.
Objective: To assess tumor behavior and the efficacy of active surveillance (AS) in patients with desmoid-type fibromatosis (DTF).
Summary Of Background Data: AS is recommended as initial management for DTF patients. Prospective data regarding the results of AS are lacking.
Tailored Beta-catenin mutational approach in extra-abdominal sporadic desmoid tumor patients without therapeutic intervention.
BMC Cancer
August 2016
Erasmus MC Cancer Institute, Rotterdam, The Netherlands.
Background: The efficacy of the classical treatment modalities surgery and radiotherapy in the treatment of aggressive fibromatosis is presently disputed and there is a shift towards a more conservative approach. The aim of the present study is to objectify tumor growth in patients with extra-abdominal or abdominal wall aggressive fibromatosis, while adhering to a "watchful waiting" policy. Other objectives are to investigate quality of life and to identify factors associated with tumor growth, in particular the relation with the presence of a CTNNB1-gene mutation in the tumor.
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