Xu et al. (https://doi.org/10.1084/jem.20240354) define NAD-induced cell death via purinergic P2RX7 receptor in type 1 unconventional T cells, particularly intrahepatic MAIT cells that are pivotal in liver homeostasis. Therefore, P2RX7 is a potential target to modulate unconventional T cells in immunopathological conditions and cancer.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11577275 | PMC |
| http://dx.doi.org/10.1084/jem.20241527 | DOI Listing |
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