AI Article Synopsis
- * Meta-analyses of three randomized controlled trials showed that UC-MSCs significantly reduced pain and improved knee function compared to the control group.
- * While the results are promising, indicating potential benefits of UC-MSCs, the authors noted the need for more studies due to the limited number of included trials.
Article Abstract
Background: This study aimed to evaluate the effects of umbilical cord mesenchymal stem cells (UC-MSCs) in the treatment of knee osteoarthritis.
Methods: PubMed, Web of Science, Cochrane Library, Embase, Chinese National Knowledge Infrastructure and Wanfang databases were searched from inception to March 31, 2024. RevMan 5.3 was used to conduct meta-analyses of the final included studies.
Results: Three randomized controlled studies were conducted. Western Ontario and McMaster Universities Osteoarthritis Index was reduced in the UC-MSCs group compared that in to the control group (mean difference: -25.85; 95% confidence interval: -41.50, -10.20; P = .001). Knee Lysholm Score was improved in the UC-MSCs group compared with the control group (mean difference: 18.33; 95% confidence interval: 12.89, 23.77; P < .00001). Egger test showed P = .583, indicating no publication bias. Sensitivity analysis indicated that the results were stable.
Conclusion: Intra-articular injection of UC-MSCs improved function and reduced pain in patients with knee osteoarthritis. However, the number of included studies was small and more studies are needed to confirm this.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11575993 | PMC |
| http://dx.doi.org/10.1097/MD.0000000000040490 | DOI Listing |
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