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Synthesis and Characterization of Thallium-Texaphyrin Nanoparticles and Their Assessment as Potential Delivery Systems for Auger Electron-Emitting Tl to Cancer Cells.
Mol Pharm
January 2025
Princess Margaret Cancer Centre, University Health Network, Toronto M5G 1L7, Canada.
Thallium-201 is an Auger electron-emitting radionuclide with significant potential for targeted molecular radiotherapy of cancer. It stands out among other Auger electron emitters by releasing approximately 37 Auger and Coster-Kronig electrons per decay, which is one of the highest numbers in its category. It has also a convenient half-life of 73 h, a stable daughter product, established production methods, and demonstrated high radiotoxicity.
View Article and Find Full Text PDFThallium-201 single photon emission computed tomography for the differentiation of malignant versus non-malignant intracranial space-occupying lesions in developing countries.
Curr Probl Cancer
February 2025
Department of Neurosciences, College of Medicine and Philippine General Hospital, University of the Philippines Manila, Manila, Philippines; Institute for Neurosciences, St. Luke's Medical Center, Quezon City & Global City, Philippines.
Background: Thallium-201 single-photon emission computed tomography (TI-SPECT) imaging has been used historically to distinguish malignant cerebral neoplasms from infectious etiologies.
Objectives: Our study aims to conduct a retrospective study, review existing literature, and perform meta-analysis on the use of TI-SPECT to differentiate malignant from non-malignant nervous system lesions when other advanced imaging modalities are not available, such as in resource-limited setting.
Methods: A retrospective study on the use of TI-SPECT in differentiating malignant versus non-malignant nervous system lesions was conducted in two tertiary hospitals in the Philippines.
Comparing the Performance of Scatter Correction Methods in Cardiac SPECT Imaging with Technetium-99m and Thallium-201 Radioisotopes.
J Med Phys
September 2024
Department of Physics, Faculty of Science, University of Mohaghegh Ardabili, Ardabil, Iran.
Purpose: This study aims to evaluate the performance of dual-energy window (DEW) and triple-energy window (TEW) scatter correction methods in cardiac SPECT imaging with technetium-99m (Tc-99m) and thallium-201 (Tl-201) radioisotopes.
Materials And Methods: The SIMIND Monte Carlo program was used to simulate the imaging system and produce the required projections. Two phantoms, including the simple cardiac phantom and the NCAT phantom, were used to evaluate the scatter correction methods.
Mechanisms of inclusion of thallium-201 into Prussian blue nanoparticles for nuclear medicine applications.
J Mater Chem B
August 2024
School of Biomedical Engineering and Imaging Sciences, King's College London, London, UK.
Article Synopsis
- Prussian blue effectively treats radiocaesium and thallium poisoning, with its nanoparticles (PBNPs) showing promise in binding radioactive thallium for nuclear medicine.
- Understanding the interaction between thallium and PBNPs is key to enhancing their performance and stability in medical applications.
- This study reveals that thallium ions can significantly alter the ionic composition of PBNPs without compromising their structural integrity, paving the way for tailored designs in nuclear medicine.
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