Individuals with balance disorders are often an overlooked population in discussions surrounding universal design. Balance disorders encompass a wide range of conditions, affecting individuals across demographics and significantly impacting their mobility and independence. Despite their prevalence and potential severity, limited guidance exists for designing spaces that effectively cater to these varied needs. This paper aims to address this critical knowledge gap by investigating the challenges faced by this diverse group in navigating their built outdoor environment, and thereby contribute valuable insights to the development of evidence-based universal design standards that better support individuals with balance disorders. Employing a combined methodological approach, this paper describes a study in which a literature review has been utilized to establish an understanding of balance disorders and their impact on navigating environments. Furthermore, it expands upon this knowledge by gathering firsthand experiences and perspectives through individual surveys, focus groups, and observations. This multifaceted approach captures diverse data on travel habits, route selection strategies, and the limitations imposed by balance disorders. The research goes beyond simply identifying challenges; it delves into the complex sensory experiences of individuals with balance disorders, including light sensitivity, dizziness, vertigo, and disorientation caused by uneven surfaces, fluctuating light conditions, and excessive noise. A crucial element of this research is recognizing the heterogeneity within the population with balance disorders.. Different individuals experience varying combinations of symptoms, leading to diverse needs and preferences in their surroundings. By analyzing this data, critical design shortcomings that contribute to navigation difficulties, as well as areas of design conflicts, are identified. Actionable recommendations for improvement and solutions to achieve a balance between the often-contrasting needs within this population are explored and proposed. Ultimately, this research aims to create a universally designed environment that fosters greater independence and participation in society for all individuals with balance disorders.
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http://dx.doi.org/10.3233/SHTI241016 | DOI Listing |
Viruses
December 2024
Animal Infectious Disease Laboratory, College of Veterinary Medicine, Yangzhou University, Yangzhou 225012, China.
The ongoing global health crisis caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) necessitates the continuous development of innovative vaccine strategies, especially in light of emerging viral variants that could undermine the effectiveness of existing vaccines. In this study, we developed a recombinant virus-like particle (VLP) vaccine based on the Newcastle Disease Virus (NDV) platform, displaying a stabilized prefusion form of the SARS-CoV-2 spike (S) protein. This engineered S protein includes two proline substitutions (K986P, V987P) and a mutation at the cleavage site (RRAR to QQAQ), aimed at enhancing both its stability and immunogenicity.
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November 2024
Department of Microbiology & Immunology, Stanford Medical School, Stanford University, Stanford, CA 94305, USA.
Cytomegaloviruses, species-specific members of the betaherpesviruses, encode an impressive array of immune evasion strategies committed to the manipulation of the host immune system enabling these viruses to remain for life in a stand-off with host innate and adaptive immune mechanisms. Even though they are species-restricted, cytomegaloviruses are distributed across a wide range of different mammalian species in which they cause systemic infection involving many different cell types. Regulated, or programmed cell death has a recognized potential to eliminate infected cells prior to completion of viral replication and release of progeny.
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December 2024
Center for Bioinformatics and Computational Biology, University of Maryland, College Park, MD 20742, USA.
Mobility tasks like the Timed Up and Go test (TUG), cognitive TUG (cogTUG), and walking with turns provide insights into the impact of Parkinson's disease (PD) on motor control, balance, and cognitive function. We assess the test-retest reliability of these tasks in 262 PD participants and 50 controls by evaluating machine learning models based on wearable-sensor-derived measures and statistical metrics. This evaluation examines total duration, subtask duration, and other quantitative measures across two trials.
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December 2024
Department of Industrial Design, Guangdong University of Technology, Guangzhou 510006, China.
Research into new solutions for wearable assistive devices for the visually impaired is an important area of assistive technology (AT). This plays a crucial role in improving the functionality and independence of the visually impaired, helping them to participate fully in their daily lives and in various community activities. This study presents a bibliometric analysis of the literature published over the last decade on wearable assistive devices for the visually impaired, retrieved from the Web of Science Core Collection (WoSCC) using CiteSpace, to provide an overview of the current state of research, trends, and hotspots in the field.
View Article and Find Full Text PDFPlants (Basel)
December 2024
College of Resources and Environment, Fujian Agriculture and Forestry University, Fuzhou 350002, China.
Excessive copper (Cu) has become a common physiological disorder restricting the sustainable production of citrus. Coumarin (COU) is a hydroxycinnamic acid that can protect plants from heavy metal toxicity. No data to date are available on the ameliorative effect of COU on plant Cu toxicity.
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