Neuroblastoma is an aggressive malignancy commonly found in children, with adult patients being quite rare. Pancreatic neuroblastoma, even among adult cases, is especially rare. We present a case of a 26-year-old woman presented with mild abdominal pain and a palpable mass diagnosed as neuroblastoma affecting the pancreas. After initial diagnostic challenges, a biopsy confirmed the diagnosis of neuroblastoma. The patient thereafter underwent a course of neoadjuvant chemotherapy, followed by a complex surgical resection. This case highlights the importance of a comprehensive diagnostic approach, including repeated biopsies and the involvement of a multidisciplinary team in the management of rare presentations of adult neuroblastoma.
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| http://dx.doi.org/10.1016/j.radcr.2024.10.066 | DOI Listing |
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- c-MYC is a crucial factor in the development of high-risk neuroblastoma, and the lack of mouse models has limited research on its mechanisms and therapy development.
- Inducing c-MYC through different promoters showed varied tumor types: using a tyrosine hydroxylase promoter led to pancreatic tumors, while a dopamine β-hydroxylase promoter resulted in neuroblastoma.
- The neuroblastoma tumors in mice exhibited similar characteristics to human neuroblastoma and responded to existing treatments, highlighting the importance of these models for testing new therapies.
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