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C-H Trifluoromethylthiolation of aldehyde hydrazones. | LitMetric

C-H Trifluoromethylthiolation of aldehyde hydrazones.

Beilstein J Org Chem

INSA Rouen Normandie, Univ Rouen Normandie, CNRS, Normandie Univ, COBRA UMR 6014, INC3M FR 3038, F-76000 Rouen, France.

Published: November 2024

The selective C-H trifluoromethylthiolation of aldehyde hydrazones afforded interesting fluorinated building blocks, which could be used as a synthetic platform. Starting from readily available (hetero)aromatic and aliphatic hydrazones, the formation of a C-SCF bond was achieved under oxidative and mild reaction conditions in the presence of the readily available AgSCF salt via a one-pot sequential process (28 examples, up to 91% yield). Mechanistic investigations revealed that AgSCF was the active species in the transformation.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11571951PMC
http://dx.doi.org/10.3762/bjoc.20.242DOI Listing

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