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| http://dx.doi.org/10.1016/j.lana.2024.100940 | DOI Listing |
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Introduction: Age-associated depletion in nicotinamide adenine dinucleotide (NAD+) concentrations has been implicated in metabolic, cardiovascular, and neurodegenerative disorders. Supplementation with NAD+ precursors, such as nicotinamide riboside (NR), offers a potential therapeutic avenue against neurodegenerative pathologies in aging, Alzheimer's disease, and related dementias. A crossover, double-blind, randomized placebo (PBO) controlled trial was conducted to test the safety and efficacy of 8 weeks' active treatment with NR (1 g/day) on cognition and plasma AD biomarkers in older adults with subjective cognitive decline and mild cognitive impairment.
View Article and Find Full Text PDFExploring Asian maternal experiences and mHealth needs for postpartum mental health care.
Digit Health
October 2024
Department of Psychiatry, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia.
Background: Mental health care during the postpartum period is notably underexplored within Asian demographics, with barriers such as stigma, privacy concerns, logistical challenges, and a shortage of mental health professionals that limits access to optimal mental healthcare. Previous studies found that mobile health (mHealth) technology has been offering a promising solution to these issues. However, the perspectives of mothers on existing mental health services and their mHealth needs are still not well understood and warrant further exploration.
View Article and Find Full Text PDFExploring emotional patterns in social media through NLP models to unravel mental health insights.
Healthc Technol Lett
January 2025
This study aimed to develop an advanced ensemble approach for automated classification of mental health disorders in social media posts. The research question was: can an ensemble of fine-tuned transformer models (XLNet, RoBERTa, and ELECTRA) with Bayesian hyperparameter optimization improve the accuracy of mental health disorder classification in social media text. Three transformer models (XLNet, RoBERTa, and ELECTRA) were fine-tuned on a dataset of social media posts labelled with 15 distinct mental health disorders.
View Article and Find Full Text PDFThe effectiveness of a drink-counting and a breathalyser-coupled smartphone application for reduced heavy drinking among alcohol-dependent adults in Sweden: A randomised controlled trial.
Addiction
January 2025
Department of Global Public Health, Karolinska Institutet, Stockholm, Sweden.
Background And Aims: Studies using smartphone apps in treatment for alcohol dependence are lacking. This study aimed to test the consumption-reducing effects of using two app-based alcohol interventions as complement to treatment as usual (TAU).
Design: Three-armed, parallel, randomised controlled trial.
Determinants of Dropout From a Virtual Agent-Based App for Insomnia Management in a Self-Selected Sample of Users With Insomnia Symptoms: Longitudinal Study.
JMIR Ment Health
January 2025
Laboratoire SANPSY, CNRS, UMR 6033, Université de Bordeaux-Centre Hospitalier Universitaire Pellegrin de Bordeaux, Bordeaux, France.
Background: Fully automated digital interventions delivered via smartphone apps have proven efficacious for a wide variety of mental health outcomes. An important aspect is that they are accessible at a low cost, thereby increasing their potential public impact and reducing disparities. However, a major challenge to their successful implementation is the phenomenon of users dropping out early.
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