To determine salivary pH in patients with Laryngopharyngeal Reflux (LPR) and compare it with that of normal individuals. A cross sectional analytical study was done. Adults with LPR as determined by Reflux Symptom Index (RSI) > 13 and Reflux Finding Score (RFS) > 7 were included in LPR group. Normal healthy adult participants with Reflux Symptom Index ≤ 3 and Reflux Finding Score ≤ 2 were included in non LPR group.32 participants were included in each groups. Salivary pH was determined in all participants using a standardized pH meter. Difference in salivary pH between two groups was statistically analyzed. The mean salivary pH in LPR group was 7.43 ± 0.77 and in non LPR group 7.0 ± 0.77. There was a statistically significant difference between the mean salivary pH between the two groups as determined by p value 0.004. The results of our exploratory study showed statistically significant difference in salivary pH between LPR and non LPR group. The salivary pH in 10(31.2%) out of 32 participants in LPR group was beyond the normal range and surprisingly the value was > 7.6, which was in contrast to acidic pH that was expected as per hypothesis. The rest 68.8% in LPR group had pH in the normal range. However salivary pH as a modality for diagnosing LPR cannot be concluded from such preliminary study with a small study population. This study forms a basis for future research for the role of salivary pH in LPR with better study designs and finer modalities of pH testing.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11569336 | PMC |
| http://dx.doi.org/10.1007/s12070-024-05109-5 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Baseline Impedance via Manometry Predicts Pathological Mean Nocturnal Baseline Impedance in Isolated Laryngopharyngeal Reflux Symptoms.
J Neurogastroenterol Motil
January 2025
Division of Gastroenterology, Taichung Veterans General Hospital, Taichung, Taiwan.
Background/aims: Distal mean nocturnal baseline impedance (MNBI) measuring via pH-impedance may be valuable in diagnosing patients with suspected laryngopharyngeal reflux (LPR). However, its wide adoption is hindered by cost and invasiveness. This study investigates whether baseline impedance measured during high-resolution impedance manometry (HRIM-BI) can predict pathological MNBI.
View Article and Find Full Text PDFSingle-Cell Transcriptome Reveals the Heterogeneity of T Cells in Mice with Systemic Lupus Erythematosus and Neuronal Inflammation.
J Inflamm Res
December 2024
Department of Dermatology, Huashan Hospital, Fudan University, Shanghai, People's Republic of China.
Introduction: Systemic lupus erythematosus is a heterogeneous autoimmune disease. A burst of autoimmune reactions in various systems can lead to severe clinical conditions closely associated with mortality. T cells serve as mediators that drive the occurrence and maintenance of inflammatory processes.
View Article and Find Full Text PDFLink between pharyngeal acid reflux episodes and the effectiveness of proton pump inhibitor therapy.
World J Gastroenterol
December 2024
School of Medicine, National Yang Ming Chiao Tung University, Taipei 112, Taiwan.
Background: Diagnosing laryngopharyngeal reflux (LPR) is challenging due to overlapping symptoms. While proton pump inhibitors (PPIs) are commonly prescribed, reliable predictors of their responsiveness are unclear. Reflux monitoring technologies like dual potential of hydrogen (pH) sensors and multichannel intraluminal impedance-pH (MII-pH) could improve diagnosis.
View Article and Find Full Text PDF[Establishment of a novel Bama minipig model of laryngopharyngeal reflux via endoscopic cricopharyngeal myotomy].
Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
December 2024
Endoscopy Center, Peking University People's Hospital, Beijing100044, China.
To establish a novel laryngopharyngeal reflux model in Bama minipigs excluding concurrent gastroesophageal reflux through endoscopic cricopharyngeal myotomy. Twelve 8-month-old male Bama minipigs were randomly assigned to three groups: Group 1 underwent cricopharyngeal myotomy alone, Group 2 underwent combined cricopharyngeal and lower esophageal sphincter myotomy, and Group 3 served as the control group. Following a one-week acclimatization period, the respective surgical procedures were performed.
View Article and Find Full Text PDF[ Granules improves thrombocytopenia in mice with systemic lupus erythematosus by suppressing platelet autophagy the Ca/CaMKK2/AMPK/mTOR signaling pathway].
Nan Fang Yi Ke Da Xue Xue Bao
December 2024
Department of Rheumatology and Immunology, First Affiliated Hospital of Anhui University of Traditional Chinese Medicine, Hefei 230031, China.
Objectives: To explore the mechanism of Granules (QJZG) for improving thrombocytopenia in a mouse model of systemic lupus erythematosus (SLE).
Methods: Twenty-four MRL/lpr lupus mice were randomized equally into 4 groups for treatment with daily gavage of saline, QJZG or prednisone (Pred) or intraperitoneal injection (twice a week) of CaMKK2 activator, with 6 C57BL/6 mice with saline gavage as the control group. After 8 weeks of treatment, the mice were examined for PLT, PCT, PDW, MPV, serum levels of TPO, IL-6, IL-10, TNF-α and IFN-γ, and calcium ion fluorescence intensity using ELISA or flow-through assay.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!