Machine learning has gained attention in the medical field. Continuous efforts are being made to develop robust models for early prognosis purposes. The brain is the most pivotal organ in the human body. A brain stroke is generally caused by a blockage in the brain arteries. A brain stroke is one of the primary reasons for death. Therefore, early prediction of diseases like brain stroke, heart attack can significantly help in making decisions for doctors. The research study aims to find a robust and potential technique for the early prediction of brain stroke, Alzheimer's, heart attack, cancer, Parkinson's and potentially reducing the incidence of severe post complications of the mentioned diseases. By considering the five datasets as input, machine learning models have been trained for the research study. Early prediction of brain stroke has been done using eight individual classifiers along with 56 other models which are designed by merging the pairs of individual models using soft and hard voting for brain stroke and eight individual classifiers have been used for early prediction of heart attack, cancer, Alzheimer and Parkinson's. After analyzing the results of each classifier for each disease, the proposed method, which is a pair of random forest and decision tree using a hard voting method for early brain stroke prediction, achieves the highest accuracy of 99%, which is better than all classifiers. Along with accuracy, the proposed method attained a value of 98% in precision, an outstanding 100% in recall, and 99% in F1 score. XGBoost performed best for cancer, Parkinson's, Alzeihmer's and Bernoulli naive bayes performed best in case of Heart attack .Upon comparing the values of these performance metrics, they outshine all the other model's values.
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http://dx.doi.org/10.1038/s41598-024-80129-3 | DOI Listing |
Pediatr Res
January 2025
Center for Genetic Medicine, Children's National Research Institute, Washington, DC, USA.
Background: Prenatally transmitted viruses can cause severe damage to the developing brain. There is unexplained variability in prenatal brain injury and postnatal neurodevelopmental outcomes, suggesting disease modifiers. Of note, prenatal Zika infection can cause a spectrum of neurodevelopmental disorders, including congenital Zika syndrome.
View Article and Find Full Text PDFNat Genet
January 2025
Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada.
Transcription factors are frequent cancer driver genes, exhibiting noted specificity based on the precise cell of origin. We demonstrate that ZIC1 exhibits loss-of-function (LOF) somatic events in group 4 (G4) medulloblastoma through recurrent point mutations, subchromosomal deletions and mono-allelic epigenetic repression (60% of G4 medulloblastoma). In contrast, highly similar SHH medulloblastoma exhibits distinct and diametrically opposed gain-of-function mutations and copy number gains (20% of SHH medulloblastoma).
View Article and Find Full Text PDFNeurotherapeutics
January 2025
Division of Neurosciences Critical Care, Johns Hopkins School of Medicine, Baltimore, MD, USA; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Department of Anesthesiology & Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA. Electronic address:
A wide range of acute brain injuries, including both traumatic and non-traumatic causes, can result in elevated intracranial pressure (ICP), which in turn can cause further secondary injury to the brain, initiating a vicious cascade of propagating injury. Elevated ICP is therefore a neurological injury that requires intensive monitoring and time-sensitive interventions. Patients at high risk for developing elevated ICP undergo placement of invasive ICP monitors including external ventricular drains, intraparenchymal ICP monitors, and lumbar drains.
View Article and Find Full Text PDFJ Neurosci
January 2025
University of Miami Miller School of Medicine, Department of Biochemistry and Molecular Biology, Miami, FL 33136.
The opioid epidemic endangers not only public health but also social and economic welfare. Growing clinical evidence indicates that chronic use of prescription opioids may contribute to an elevated risk of ischemic stroke and negatively impact post-stroke recovery. In addition, NLRP3 inflammasome activation has been related to several cerebrovascular diseases, including ischemic stroke.
View Article and Find Full Text PDFBMJ Open Qual
January 2025
Division of Cardiovascular Sciences, The University of Manchester, Manchester, UK.
Introduction: Stroke is a leading cause of mortality and morbidity, demanding prompt and accurate identification. However, prehospital diagnosis is challenging, with up to 50% of suspected strokes having other diagnoses. A prehospital video triage (PHVT) system was piloted in Greater Manchester to improve prehospital diagnostic accuracy and appropriate conveyance decisions.
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