AI Article Synopsis
- Innate immune responses are essential for maintaining balance in the body, and they are triggered by specific receptors on immune cells.
- CD209 is one of these receptors found on macrophages and dendritic cells that is key for immune functions, but its effect on certain immune cells is not well understood.
- In a study, researchers identified three genes in zebrafish that are similar to human CD209 and found that one of them regulates macrophage activity and impacts neutrophil development, highlighting its potential role in innate immunity.
Article Abstract
Innate immune responses play a crucial role in maintaining homeostasis, their initiation closely related to pattern recognition receptors or damage-associated molecules on the surface of innate immune cells. CD209, a pattern recognition receptor on the surface of macrophages or dendritic cells, plays an important role in immune functions. However, the impact of CD209 on innate immune cells such as macrophages or neutrophils remains unclear. In this study, through multiple sequence alignment and phylogenetic tree construction, three genes homologous to human CD209 were found in zebrafish. These are (Ensembl ID:ENSDARG00000029461), (Ensembl ID:ENSDARG00000059049) and (Ensembl ID: ENSDARG00000096624).Compared to the and genes in the Ensembl database, is more similar to human CD209 in sequence. Using whole-mount hybridization and fluorescence co-localization experiments, it was found that is mainly expressed in macrophages. Further morpholino knockdown experiments showed that knocking down leads to an upregulation of M1-type macrophage-related genes and a decrease in the number of mature neutrophils, indicating that is functionally more similar to CD209. These findings not only reveal the potential role of CD209 in regulating macrophage function and neutrophil development but also provide significant insights for research into the mechanisms of innate immunity.
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| http://dx.doi.org/10.16288/j.yczz.24-181 | DOI Listing |
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