A two-step formal (4 + 1) annulation-dehydration reaction offers a convenient route to C2-arylated indoles and benzofurans. This reaction exploits the bifunctional reactivity of electron-deficient benzyl chlorides with -sulfonyl-2-aminobenzaldehydes or salicylaldehyde derivatives. The reaction tolerates both electron-withdrawing and donating groups on the substituted aldehydes, as well as variation of electron-withdrawing groups at the position of the benzyl chloride reagent. This work also identifies interesting byproducts resulting from the self-reaction of these benzyl chlorides under basic conditions.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1021/acs.joc.4c02231 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Evaluation of Performance and Stability of a Gel-Type Polymer Sorbent for Recovery of Phosphate from Waste Streams.
ACS Appl Polym Mater
December 2024
School of Chemistry and Chemical Engineering, Queen's University, David Keir Building, Stranmillis Road, BT9 5AG Belfast, Northern Ireland, U.K.
Phosphorus (P) fertilizer is an essential component of our food system with the majority of all mined P rock processed to make mineral fertilizers. Globally however P rock stocks are declining-both in quality and quantity-with poor P management creating a linear economic system where P is mined, globally redistributed into products and eventually discharged into the environment leading to eutrophication. To enable establishment of a circular P economy, whereby P can be recovered from waste for its industrial reuse, requires the development of effective P recovery technologies.
View Article and Find Full Text PDFProduction of benzyl-based esters from used soybean cooking oil as renewable plasticizers for flexible PVC films: Exploring new applications for lipases in emerging technologies.
Int J Biol Macromol
December 2024
Graduate Program in Chemistry, Federal University of Alfenas, Alfenas, MG 37130-001, Brazil; Institute of Chemistry, Federal University of Alfenas, Alfenas, MG 37130-001, Brazil. Electronic address:
The objective of this study was to produce new and renewable bio-based plasticizers from used soybean cooking oil (USCO). First, USCO was completely converted into free fatty acids (FFAs) using lipase from Candida rugosa. Next, these FFAs were enzymatically esterified with benzyl alcohol in solvent-free systems.
View Article and Find Full Text PDFTwo novel triazine-based quaternary ammonium salt Gemini surfactants as potential corrosion inhibitors for carbon steel in a sulfate-reducing bacteria solution: Experimental and theoretical studies.
Heliyon
December 2024
School of Chemistry and Chemical Engineering, North University of China, Taiyuan, 030051, Shanxi, China.
In this paper, two triazine ring-containing quaternary ammonium salt Gemini surfactants (C-2-C and C-2-C) were synthesized. The minimum inhibitory concentrations against sulfate-reducing bacteria (SRB) of C-2-C, C-2-C and dodecyl dimethyl benzyl ammonium chloride (1227) were determined using the double-dilution method. The performance of C-2-C and C-2-C in inhibiting carbon steel corrosion in the presence of SRB was examined, with 1227 serving as a control sample.
View Article and Find Full Text PDF[Effect of electroacupuncture on neurological function in rats with cerebral ischemia-reperfusion injury based on AMPK/mTOR/ULK1 signaling pathway].
Zhongguo Zhen Jiu
December 2024
Clinical Medical College of Acupuncture-Moxibustion and Rehabilitation, Guangzhou University of CM, Guangzhou 510006, Guangdong Province, China; Second Clinical College of Guangzhou University of CM, Guangzhou 510120, Guangdong Province; Department of Rehabilitation, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou 510120; Guangdong Provincial Key Laboratory of TCM Prevention and Treatment of Intractable Chronic Diseases, Guangzhou 510120.
Objective: To investigate the effect of electroacupuncture (EA) on neurological function in rats with cerebral ischemia-reperfusion injury (CIRI) by regulating adenosine monophosphate-activated protein kinase (AMPK)/mammalian target of rapamycin (mTOR)/Unc-51-like kinase 1 (ULK1) signaling pathway.
Methods: Thirty-three male SD rats were randomly divided into a sham-operation group, a model group and an EA group, with 11 rats in each group. The right middle cerebral artery occlusion/reperfusion (MCAO/R) model was prepared by thread occlusion method in the model group and the EA group.
Repurposing First-Row Transition Metal Carbon Dioxide Reduction Electrocatalysts for Electrochemical Carboxylation of Benzyl Chloride.
ACS Org Inorg Au
December 2024
Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Mahidol University, Bangkok, 10400, Thailand.
Carbon dioxide (CO) is an abundant and useful C feedstock for electrocarboxylation, a process that incorporates a carboxyl moiety into an organic molecule. In this work, three first-row transition metal CO reduction electrocatalysts, NiPDI (), NiTPA (), and Fe(salenCl) (), were explored as electrocarboxylation catalysts with benzyl chloride as a substrate. The cyclic voltammograms of all three catalysts showed current enhancements in the presence of benzyl chloride under a CO atmosphere.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!