Humans are skillful at manipulating objects that possess nonlinear underactuated dynamics, such as clothes or containers filled with liquids. Several studies suggested that humans implement a predictive model-based strategy to control such objects. However, these studies only considered unconstrained reaching without any object involved or, at most, linear mass-spring systems with relatively simple dynamics. It is not clear what internal model humans develop of more complex objects, and what level of granularity is represented. To answer these questions, this study examined a task where participants physically interacted with a nonlinear underactuated system mimicking a cup of sloshing coffee: a cup with a ball rolling inside. The cup and ball were simulated in a virtual environment and subjects interacted with the system via a haptic robotic interface. Participants were instructed to move the system and arrive at a target region with both cup and ball at rest, 'zeroing out' residual oscillations of the ball. This challenging task affords a solution known as 'input shaping', whereby a series of pulses moves the dynamic object to the target leaving no residual oscillations. Since the timing and amplitude of these pulses depend on the controller's internal model of the object, input shaping served as a tool to identify the subjects' internal representation of the cup-and-ball. Five simulations with different internal models were compared against the human data. Results showed that the features in the data were correctly predicted by a simple internal model that represented the cup-and-ball as a single rigid mass coupled to the hand impedance. These findings provide evidence that humans use simplified internal models along with mechanical impedance to manipulate complex objects.
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http://dx.doi.org/10.1371/journal.pcbi.1012599 | DOI Listing |
Res Social Adm Pharm
January 2025
Institute of Health Policy, Management and Evaluation, University of Toronto, 155 College Street, Suite 425, Toronto, Ontario, M5T 3M6, Canada; Research & Innovation, North York General Hospital, 4001 Leslie Street, Toronto, Ontario, M2K 1E1, Canada.
Purpose: Diversion or theft of controlled substances is a recognized problem affecting healthcare systems globally. The purpose of this study was to develop a framework for identifying and characterizing system factors leading to vulnerabilities for diversion within hospitals.
Methods: We applied a qualitative framework method, which involved 1) compiling a list of critical diversion vulnerabilities through observations and proactive risk analyses in the inpatient pharmacy, emergency department and intensive care unit of two Canadian hospitals; 2) coding the vulnerabilities into deductively and inductively derived themes and subthemes; and 3) building a conceptual framework.
J Formos Med Assoc
January 2025
Division of Nephrology, Department of Internal Medicine, National Cheng Kung University Hospital, College of Medicine, National Cheng-Kung University, Tainan, Taiwan; Institute of Clinical Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan. Electronic address:
Background: Quality of life (QOL) is important for evaluating medical care outcomes. In chronic kidney disease (CKD) population, generic instruments, such as WHOQOL-BREF and EQ-5D, are commonly used for comparing various medical conditions for policy-making purposes. However, their psychometric properties have not yet been validated in non-dialysis CKD population.
View Article and Find Full Text PDFJ Affect Disord
January 2025
Department of Psychiatry and Psychotherapy, University of Marburg, Germany; Center for Mind, Brain and Behavior (CMBB), University of Marburg, Germany.
Background: Major depressive disorder (MDD) comes along with an increased risk of recurrence and poor course of illness. Machine learning has recently shown promise in the prediction of mental illness, yet models aiming to predict MDD course are still rare and do not quantify the predictive value of established MDD recurrence risk factors.
Methods: We analyzed N = 571 MDD patients from the Marburg-Münster Affective Disorder Cohort Study (MACS).
Atherosclerosis
December 2024
Rehabilitation Division, Sheba Medical Center, Tel-Hashomer, Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
Background And Aims: Several systemic autoimmune diseases predispose to the enhancement of Atherosclerotic Cardiovascular Disease (ASCVD). These findings underline the role of inflammation in atherogenesis. Dermatomyositis (DM) and polymyositis (PM) are polygenic autoimmune disorders involving mainly skeletal muscles.
View Article and Find Full Text PDFJ Card Fail
January 2025
Division of General Internal Medicine, Department of Medicine, Weill Cornell Medicine, New York, NY; Division of Cardiology, Department of Medicine, Weill Cornell Medicine, New York, NY. Electronic address:
Background: Inflammation plays a key role in the development of heart failure (HF), and diet is a known modifiable factor that modulates systemic inflammation. The dietary inflammatory score (DIS) is a tool to quantify the inflammatory components of diet. We sought to determine whether the DIS is associated with incident HF events.
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