AI Article Synopsis
- Traditional clinical criteria for diagnosing Kawasaki disease (KD) can be ambiguous and may resemble other common childhood illnesses, highlighting the need for reliable biomarkers.
- A review of various studies emphasizes both widely used biomarkers like NT-ProBNP and ferritin, as well as promising new candidates identified through modern techniques like transcriptomics and proteomics.
- Expert opinion suggests that while advancements in identifying KD biomarkers are encouraging, further validation, larger studies, and standardization of cutoff values are necessary for these markers to become practical in clinical settings.
Article Abstract
Introduction: Currently the diagnosis of Kawasaki disease is still heavily reliant on clinical criteria which may be subject to interpretation or mimic other common febrile diseases of childhood. Biomarkers that can aid in the accurate and timely diagnosis of KD are of great clinical utility.
Areas Covered: A literature search of PubMed was performed using the key words: Kawasaki disease, diagnosis, biomarkers, proteomics and transcriptomics. In this article we review biomarkers that are widely clinically available including NT-ProBNP and ferritin. We also include promising novel biomarkers that have been identified through newer transcriptomic and proteomic techniques.
Expert Opinion: While the identification of biomarkers that can accurately assist in diagnosing patients with KD is a promising field of research, more still remains to be done to in order to validate new biomarkers in larger cohorts, and to set standardized cutoff values for potential biomarkers that are currently clinically available. Further research is needed before KD biomarkers that are consistent, readily available, and cost-effective can be a clinical reality.
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Source |
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| http://dx.doi.org/10.1080/14737159.2024.2432025 | DOI Listing |
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