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Background: Recruiting large numbers of study participants for Alzheimer's Disease (AD) drug trials remains a significant challenge in need of more effective approaches. Advertising can be an effective way to reach large numbers of prospective participants, but can suffer from low attendance rates. This study examined the relationship between the initial behaviors of prospective AD trial participants who did not attend their first scheduled appointment and their overall likelihood of eventually attending an in-person consultation.
View Article and Find Full Text PDFBackground: In AD trials, the treatment effect is typically evaluated by estimating the absolute difference in change from baseline to the end-of-study visit (e.g., 18 months) between treatment arms using the MMRM model.
View Article and Find Full Text PDFSimultaneous Concentration and T Mapping of Brain Metabolites by Fast Multi-Echo Spectroscopic Imaging.
NMR Biomed
February 2025
MR Methodology, Department for Diagnostic and Interventional Neuroradiology, University of Bern, Bern, Switzerland.
The purpose of this study was to produce metabolite-specific T and concentration maps in a clinically compatible time frame. A multi-TE 2D MR spectroscopic imaging (MRSI) experiment (multi-echo single-shot MRSI [MESS-MRSI]) deployed truncated and partially sampled multi-echo trains from single scans and was combined with simultaneous multiparametric model fitting. It was tested in vivo for the brain in five healthy subjects.
View Article and Find Full Text PDFUnlocking advanced thermometric capabilities: BiVO: Er/Yb nanophosphors with dual-mode up-conversion and down-shifting features.
RSC Adv
January 2025
Department of Condensed Matter Physics, GdS Optronlab, LUCIA Building, University of Valladolid Paseo de Belén 19 47011 Valladolid Spain.
Luminescent materials doped with rare-earth (RE) ions have emerged as powerful tools in thermometry, offering high sensitivity and accuracy. However, challenges remain, particularly in maintaining efficient luminescence at elevated temperatures. This study investigates the thermometric properties of BiVO: Yb/Er (BVO: Er/Yb) nanophosphors synthesized the sol-gel method.
View Article and Find Full Text PDFVR Cognitive-based Intervention for Enhancing Cognitive Functions and Well-being in Older Adults with Mild Cognitive Impairment: Behavioral and EEG Evidence.
Psychosoc Interv
January 2025
Burapha University Faculty of Humanities and Social Sciences Department of Psychology Thailand Department of Psychology, Faculty of Humanities and Social Sciences, Burapha University, Thailand.
Mild cognitive impairment (MCI) has been recognized as a window of opportunity for therapeutic and preventive measures to slow cognitive decline. The current study investigated the efficacy of the virtual reality (VR) cognitive-based intervention on verbal and visuospatial short-term memory (STM), executive functions (EFs), and wellbeing among older adults with and without MCI. The immersive VR cognitive-based intervention comprised eight 60-minute sessions, held twice a week over a span of 30 days.
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