The effects of different doses of single- and dual-wavelength whole-body photobiomodulation on metabolic parameters in obese mice.

Photobiomodulation (PBM) shows beneficial effects on obesity-related alterations. It is not known if dual- is more beneficial than single-wavelength, nor the dose-response effect of such treatments. The effects of different doses of single- and dual-wavelength whole-body PBM on metabolic parameters in obese mice were evaluated. Male Swiss albino mice were fed with standard (Chow) or a cafeteria (CAF) diet and allocated into Sham (lights off), and PBM (whole-body blanket (140 cm) composed of 20 LED clusters, 2.14 mW/cm/cluster, for 67 or 133 s: 1 or 2 J per cluster; 20 and 40 J total energy; and 0.143 and 0.286 J/cm) with 660 nm (660), 850 (850) nm, or 660 nm + 850 nm (660/850). CAF induced insulin resistance that was inhibited in 660-1, 660-2, 850-1, and 660/850-2. CAF increased serum total cholesterol that was inhibited in 660-1, 660-2, 850-1, 660/850-1, and 660/850-2. There were no PBM-induced changes in other variables assessed. The effects of whole-body PBM in metabolic paraments in obese mice were wavelength and dose dependent: increasing the dose for 660 did not affect the outcomes; increasing the dose for 850 negatively affected the outcomes, and increasing the dose for 660/850 was mostly beneficial on the outcomes.