AI Article Synopsis
- PAX3 is essential for embryonic muscle development, aiding in the growth and differentiation of muscle progenitor cells.
- The role of PAX3 in adult muscle maintenance and regeneration is not well understood, with muscle stem cells showing varying levels of PAX3 expression.
- This research investigates how different PAX3 expression levels in satellite cells affect their response to tissue damage, aiming to unlock insights for potential treatments for muscle-related diseases.
Article Abstract
PAX3 plays a crucial role in embryonic myogenesis, controlling the specification, migration, proliferation, and differentiation of muscle progenitor cells to ensure normal skeletal muscle development in the embryo. However, PAX3 potential role in a context of muscle homeostasis and regeneration remains poorly investigated. The adult muscle stem cells, known as satellite cells (SCs) exhibit heterogeneity in Pax3 expression in various muscles throughout the body and display a bimodal response to environmental stress exposure. To explore the role of PAX3 in the context of tissue damage, we performed regeneration studies, which unveiled a functional heterogeneity of the SCs populations depending on Pax3 expression. Together, this project aims to decipher cell-type specific dysregulations linked to tissue damage and identify PAX3 downstream gene regulatory networks that can lead to specific SC behavior, thus potentially providing novel strategies for muscle disease preventive therapies.
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| http://dx.doi.org/10.1051/medsci/2024139 | DOI Listing |
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