AI Article Synopsis
- The chemistry community is focused on creating sustainable methods for building complex chiral molecules that can be transformed in various ways.
- This study presents a new copper(I)-catalyzed reaction that allows for enyne addition to aldehydes without needing pre-prepared nucleophiles.
- The new method effectively adds chiral allylic alcohols to a wide range of substrates with great precision in regio-, stereo-, and enantioselectivity.
Article Abstract
The development of sustainable and novel strategies for constructing complex chiral molecules with versatile transformation potential is a long-term pursuit in the chemistry community. We report a copper(I)-catalyzed enyne addition to aldehydes under proton-transfer conditions, unlike previous examples which were limited to the use of preformed reactive nucleophiles containing allylic heteroatoms or electron-withdrawing groups. This protocol provides an efficient platform for installing chiral allylic alcohol moieties with a broad substrate scope and high regio-, stereo-, and enantioselectivity.
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| http://dx.doi.org/10.1021/acs.orglett.4c03449 | DOI Listing |
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