AI Article Synopsis
- Researchers created new epoxyazadiradione-thiazole hybrids to find natural product-based anticancer agents.
- Most of these new compounds showed strong cytotoxic effects on cancer cells while being less harmful to normal cells, especially one compound effective against tongue cancer.
- Further tests indicated that this compound disrupts the cell cycle in tongue cancer cells and triggers early apoptosis, suggesting it could be a promising candidate for future anticancer drug development.
Article Abstract
In an attempt to develop natural product-based anticancer agents, a series of novel epoxyazadiradione-thiazole hybrids () were synthesised and evaluated for their anticancer activity. All the synthesised derivatives were assessed for cytotoxic activity against a panel of human cancer and normal cell lines and the results showed that most of the compounds exhibited significant cytotoxic activity against cancer cells and as well some of the compounds showed less cytotoxicity against normal cells. In particular, compound showed potent cytotoxic activity against tongue cancer cell lines. In consideration of the potent activity, the compound was further assessed for cell cycle analysis and the results showed that the compound arrests the cell cycle progression at the G0/G1 phase in the tongue cancer cell lines. Consequently, the annexin V/PI staining assay demonstrated that compound induced early apoptosis against tongue cancer. Taken together, the results inferred that the epoxyazadiradione is promising anticancer candidate for developing novel anticancer drugs against tongue cancer.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1080/14786419.2024.2429130 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!