AI Article Synopsis
- 5'-Noraristeromycin, a mixture of two enantiomers, has strong cytotoxic effects on leukemia cells, with different effectiveness across cell lines (Jurkat, K562, THP-1).
- In toxicity studies on white mice, the lethal dose (LD) of 5'-noraristeromycin was found to be around 63.2 mg/kg, with notable doses causing varying levels of acute toxicity.
- Administering this substance leads to systemic damage to the internal organs and tissues of the mice, indicating significant health risks at certain dosage levels.
Article Abstract
5'-Noraristeromycin as a racemic mixture of enantiomers was found to exhibit a pronounced cytotoxic effect on leukemia cells; IC for the Jurkat, K562, and THP-1 cell lines was 7.3, 1.3, and 3.7 μM, respectively. The general toxicity of 5'-noraristeromycin was studied in experiments on white mice upon single-dose intragastric administration; toxicometric parameters were determined, and the clinical and pathomorphological presentation of acute intoxication was studied. LD of the substance was shown to be 63.2 (52.7÷75.8) mg/kg; LD16, 44.7 mg/kg, and LD84, 89.4 mg/kg. Administration of the substance at a dose within the studied dose range is accompanied by systemic damage to the internal organs and tissues of the experimental animals.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11569843 | PMC |
| http://dx.doi.org/10.32607/actanaturae.27443 | DOI Listing |
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