Clinical immunotherapy in glioma: current concepts, challenges, and future perspectives.

Front Immunol

Department of Neurosurgery, West China Hospital, Sichuan University, Chengdu, Sichuan, China.

Published: November 2024

AI Article Synopsis

  • Glioma is a common brain tumor with traditional treatments like surgery and chemotherapy that often do not work well and have unclear outcomes.
  • Recent advancements in immunology and genomics are paving the way for new immunotherapy approaches that have shown success in other cancers.
  • This review highlights new immunotherapy methods for glioma, discusses the progress of ongoing clinical trials, and examines the challenges and future potential of glioma immunotherapy.

Article Abstract

Glioma is one of the common tumors in the central nervous system, and its treatment methods (surgery, radiotherapy, and chemotherapy) lack specificity and have a poor prognosis. With the development of immunology, cell biology, and genomics, tumor immunotherapy has ushered in a new era of tumor therapy, achieving significant results in other invasive cancers such as advanced melanoma and advanced non-small cell lung cancer. Currently, the clinical trials of immunotherapy in glioma are also progressing rapidly. Here, this review summarizes promising immunotherapy methods in recent years, reviews the current status of clinical trials, and discusses the challenges and prospects of glioma immunotherapy.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11564147PMC
http://dx.doi.org/10.3389/fimmu.2024.1476436DOI Listing

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