AI Article Synopsis
- Small VCP Interacting Protein (SVIP) is crucial for the formation of tubular lysosomes (TLs) within certain cells.
- In studies, expressing SVIP in the intestine leads to the continuous formation of TLs, boosts autophagic activity, and promotes a longer healthspan.
- Human SVIP can mimic some of these effects when expressed in the gut, but its impact is generally weaker than the original SVIP.
Article Abstract
Small VCP Interacting Protein (SVIP) is essential for maintaining a unique form of tubular lysosomes (TLs) in . Although do not have an annotated ortholog, expression of in the intestine induces TLs constitutively, increases autophagic activity, and extends healthspan. Here, we find that expression of the human ortholog of in the gut causes similar physiological and phenotypic effects as , albeit some effects were less pronounced. These results demonstrate that human can induce functional TLs in but may be a weaker allele compared to .
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11568451 | PMC |
| http://dx.doi.org/10.17912/micropub.biology.001379 | DOI Listing |
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