Neuropsychiatric disorders (NPDs) pose a substantial burden on the healthcare system. The major challenge in diagnosing NPDs is the subjective assessment by the physician which can lead to inaccurate and delayed diagnosis. Recent studies have depicted that the integration of artificial intelligence (AI) in neuropsychiatry could potentially revolutionize the field by precisely diagnosing complex neurological and mental health disorders in a timely fashion and providing individualized management strategies. In this narrative review, the authors have examined the current status of AI tools in assessing neuropsychiatric disorders and evaluated their validity and reliability in the existing literature. The analysis of various datasets including MRI scans, EEG, facial expressions, social media posts, texts, and laboratory samples in the accurate diagnosis of neuropsychiatric conditions using machine learning has been profoundly explored in this article. The recent trials and tribulations in various neuropsychiatric disorders encouraging future scope in the utility and application of AI have been discussed. Overall machine learning has proved to be feasible and applicable in the field of neuropsychiatry and it is about time that research translates to clinical settings for favorable patient outcomes. Future trials should focus on presenting higher quality evidence for superior adaptability and establish guidelines for healthcare providers to maintain standards.
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http://dx.doi.org/10.7759/cureus.71651 | DOI Listing |
Pediatr Dermatol
January 2025
Section of Pediatric Dermatology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
Oral N-acetylcysteine (NAC) has shown efficacy for debilitating habit-driven and neuropsychiatric disorders in small, mostly adult studies. We retrospectively evaluated the therapeutic use and safety of oral NAC in 93 children from the Children's Hospital of Philadelphia. This study supports the use of oral NAC for habit-driven skin, hair, and nail abnormalities in pediatric patients.
View Article and Find Full Text PDFPsychiatry Clin Neurosci
January 2025
Department of Neuropsychiatry, Kochi Medical School, Kochi University, Kochi, Japan.
Aim: Despite the clinical importance and significant social burden of neuropsychiatric symptoms (NPS) in dementia, the underlying neurobiological mechanism remains poorly understood. Recently, neuroimaging-derived brain-age estimation by machine-learning analysis has shown promise as an individual-level biomarker. We investigated the relationship between NPS and brain-age in amnestic mild cognitive impairment (MCI) and early dementia.
View Article and Find Full Text PDFSubcell Biochem
January 2025
Epigenetic Editing, Department of Pathology and Medical Biology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Brain disorders, especially neurodegenerative diseases, affect millions of people worldwide. There is no causal treatment available; therefore, there is an unmet clinical need for finding therapeutic options for these diseases. Epigenetic research has resulted in identification of various genomic loci with differential disease-specific epigenetic modifications, mainly DNA methylation.
View Article and Find Full Text PDFJ Affect Disord
January 2025
Department of Neurology, The First Affiliated Hospital of Anhui Medical University, 218 Jixi Road, Anhui Province, Hefei 230022, China; Department of Neurology, The Second Affiliated Hospital of Anhui Medical University, Hefei 230601, China; Department of Psychology and Sleep Medicine, The Second Affiliated Hospital of Anhui Medical University, Hefei 230601, China. Electronic address:
Background: Electroconvulsive therapy (ECT) is an effective treatment for patients with major depressive disorder (MDD), but the underlying neuromodulatory mechanisms remain largely unknown. Functional stability represents a newly developed method based on the dynamic functional connectivity framework. This study aimed to explore ECT-evoked changes in functional stability and their relationship with clinical outcomes.
View Article and Find Full Text PDFExp Gerontol
January 2025
Shanghai anti-doping Laboratory, Shanghai University of Sport, Shanghai 200438, China; Department of Rheumatology and Immunology, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200240, China. Electronic address:
Aging is a complex biological process characterized by increased inflammation and susceptibility to various age-related diseases, including cognitive decline, osteoporosis, and type 2 diabetes. Exercise has been shown to modulate mitochondrial function, immune responses, and inflammatory pathways, thereby attenuating aging through the regulation of exerkines secreted by diverse tissues and organs. These bioactive molecules, which include hepatokines, myokines, adipokines, osteokines, and neurokines, act both locally and systemically to exert protective effects against the detrimental aspects of aging.
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