This article presents the case of a 52-year-old male who arrived at the emergency department with escalating chest pain and shortness of breath. An urgent CT scan revealed a right pulmonary embolism and inferior vena cava thrombus, prompting immediate anticoagulant therapy. Further diagnostic evaluations confirmed nephrotic syndrome (NS). The patient was discharged on apixaban, ramipril, amlodipine, and atorvastatin. A subsequent renal biopsy showed features consistent with minimal change disease, which resolved spontaneously without the need for steroid treatment. This case highlights the potentially life-threatening presentation of multiple venous thromboses as an initial manifestation of NS.
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http://dx.doi.org/10.7759/cureus.71698 | DOI Listing |
Theranostics
January 2025
Department of Nephrology, China-Japan Friendship Hospital (Institute of Clinical Medical Sciences), Beijing, 100029, China.
The tertiary structure of normal podocytes prevents protein from leaking into the urine. However, observing the complexity of podocytes is challenging because of the scale differences in their three-dimensional structure and the close proximity between neighboring cells in space. In this study, we explored podocyte-secreted angiopoietin-like 4 (ANGPTL4) as a potential morphological marker via super-resolution microscopy (SRM).
View Article and Find Full Text PDFLife (Basel)
December 2024
Department of Nephrology, Faculty of Medicine, University of Medicine and Pharmacy "Carol Davila", 050474 Bucharest, Romania.
Background: Despite extensive research on proteinuria's impact on chronic kidney disease progression, there is no direct comparison of outcomes in biopsy-diagnosed glomerular disease (GD) patients with nephrotic syndrome (NS) or nephrotic range proteinuria (NRP). Our study addresses this gap, comparing long-term outcomes between NS and NRP.
Methods: We conducted a retrospective study on 240 kidney biopsy-proven GD patients, tracked from 2010 to 2015 until end-stage kidney disease (ESKD), death, or the study end in January 2022.
Biomedicines
December 2024
Department of Cardiology and Nephrology, Mie University Graduate School of Medicine, Tsu 514-8507, Japan.
Nephrotic syndrome (NS) is characterized by massive proteinuria, hypoproteinemia, and edema [...
View Article and Find Full Text PDFArch Esp Urol
December 2024
Pediatric Surgery, Qilu Hospital of Shandong University, 250012 Jinan, Shandong, China.
Background: Doxorubicin (DOX) is a widely used anticancer drug; However, its nephrotoxicity limits its therapeutic efficacy. This study investigates the protective effects of Perilla Alcohol (PA) against DOX-induced nephrotic syndrome (NS), focusing on its antioxidant and anti-inflammatory properties through the nuclear factor erythroid 2-related factor 2 (Nrf2) and nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) pathways.
Methods: A DOX-induced nephrotic syndrome (NS) rat model and a DOX-treated Mouse Podocyte Cell line 5 (MPC5) cell model were used to evaluate the renal protective effects of PA.
Front Pediatr
December 2024
Department of Pediatrics, The First Hospital of Quanzhou Affiliated to Fujian Medical University, Quanzhou, Fujian, China.
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