Resource-limited burn centers are usually devoid of cultured epithelial autografts (CEA) owing largely to prohibitive costs. A modified CEA technique at our burn center incorporated cost-effective, routinely-used dressings with favorable outcomes. One unknown concern was the immunosuppressive effect that extensive burns and potentially human immunodeficiency virus (HIV) infection may have on graft take. This case study reports on the graft take outcomes of the first CEA transplanted in an HIV-positive patient with extensive burns in South Africa, using this technique. Graft take was determined after 21 days at 80% and a long-term follow-up of 8 years indicated good pigmentation return and skin pliability. Delayed diagnosis of pyoderma gangrenosum caused partial graft loss; however, successful regrafting occurred after pyoderma gangrenosum treatment and eradication. The case was considered clinically successful. HIV may not directly affect graft take, but may result in immunosuppressive conditions that delay graft take success.
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http://dx.doi.org/10.1055/s-0044-1782540 | DOI Listing |
Anaerobe
December 2024
Division of Medical Microbiology and Immunology, Department of Pathology, Faculty of Medicine and Health Sciences, Stellenbosch University, Francie van Zilj Drive, Parow, Cape Town, Western Cape, 7505, South Africa; National Health Laboratory Service, Tygerberg, Western Cape, South Africa. Electronic address:
Objectives: To describe Clostridioides difficile infection (CDI) rates and testing practices, at three tertiary/quaternary hospitals in South Africa (SA) for the period 2017 to 2020.
Methods: A retrospective laboratory record review of all C. difficile testing at the Charlotte Maxeke Johannesburg Academic Hospital (CMJAH), Tygerberg Hospital (TBH) and Inkosi Albert Luthuli Central Academic Hospital (IALCH) was performed.
Sci Total Environ
December 2024
Université de Lille, CNRS, Université du Littoral Côte d'Opale, IRD, UMR 8187, LOG, Laboratoire d'Océanologie et de Géosciences, Station marine de Wimereux, F-59000 Lille, France; Department of Marine Resources and Energy, Tokyo University of Marine Science and Technology, 4-5-7 Konan, Minato-ku, Tokyo 108-8477, Japan; Department of Zoology and Entomology, Rhodes University, Grahamstown 6140, South Africa.
The ever-growing contamination of the environment by plastics is a major scientific and societal concern. Specifically, the study of microplastics (1 μm to 5 mm), nanoplastics (< 1 μm), and their leachates is a critical research area as they have the potential to cause detrimental effects, especially when they impact key ecological species. Marine mussels, as ecosystem engineers and filter feeders, are particularly vulnerable to this type of pollution.
View Article and Find Full Text PDFNurs Open
December 2024
School of Nursing, Johns Hopkins University, Baltimore, Maryland, USA.
Aim: To discuss the need to expand advanced practice nurse education in Sub-Saharan Africa as a strategic response to the impact of the COVID-19 pandemic.
Design: Discursive paper.
Method: Searching international literature in PubMed, CINAHL and Google Scholar databases, we explored the impact of COVID-19 in Sub-Saharan Africa and the advanced practice nurse role and education in the pandemic response.
Eur J Vasc Endovasc Surg
December 2024
Wits Donald Gordon Medical Centre, Johannesburg, South Africa.
Bone
December 2024
Division of Clinical Anatomy, Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Stellenbosch University Tygerberg Campus, PO Box 241, Cape Town 8000, South Africa. Electronic address:
Obesogenic feeding can affect systemic metabolism and impact bone health and microarchitecture, but the findings of published studies often appear contradictory. This study aimed to compare the effects of a medium-fat/high-sugar (MF/HS) and a high-fat/high-fructose (HF/Fr) diet on the femora of weanling male Wistar rats, examining bone mineral content and density (BMC, BMD), cortical and cancellous bone microarchitecture and the cell populations within bone. Furthermore, we explored the correlations between circulating bone-targeting factors (in particular leptin, adiponectin and insulin) and bone parameters.
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