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Deep learning-integrated MRI brain tumor analysis: feature extraction, segmentation, and Survival Prediction using Replicator and volumetric networks.
Sci Rep
January 2025
Department of Computer Engineering, Inha University, Incheon, Republic of Korea.
The most prevalent form of malignant tumors that originate in the brain are known as gliomas. In order to diagnose, treat, and identify risk factors, it is crucial to have precise and resilient segmentation of the tumors, along with an estimation of the patients' overall survival rate. Therefore, we have introduced a deep learning approach that employs a combination of MRI scans to accurately segment brain tumors and predict survival in patients with gliomas.
View Article and Find Full Text PDFBiomarkers.
Alzheimers Dement
December 2024
Geroscience Center for Brain Health and Metabolism (GERO), Santiago, Chile.
Background: Chronic exposure to stress, quantified by allostatic load (AL), has been postulated as a cause of structural brain changes in the context of dementia. White matter hyperintensities (WMH), detected in MRI FLAIR, are a common brain abnormality representing small vessel disease or degenerative changes in the brain. Here, we studied differences in tract-specific WMH volume across three risk levels of AL in Chilean subjects with cognitive complaint, to explore links between chronic stress exposure and prodromal steps of dementia.
View Article and Find Full Text PDFBackground: Neurodevelopmental origins of functional variation through the lifespan are acknowledged, but pathways need to be identified. The objectives of the project Set-to-change is to test whether and how early life environmental factors and genetic makeup regulate brain and cognition and its change, as well as neurocognitive plasticity in response to training through the lifespan.
Method: Preliminary analyses for the first months are presented.
Biomarkers.
Alzheimers Dement
December 2024
Normandie Univ, UNICAEN, INSERM, U1237, PhIND "Physiopathology and Imaging of Neurological Disorders", NeuroPresage Team, GIP Cyceron, Caen, France.
White matter hyperintensities (WMH) are highly prevalent in aging and Alzheimer's disease (AD) and typically attributed to vascular damage and cerebral small vessel disease. Yet, several lines of evidence from the literature emphasize the heterogeneity in the mechanisms leading to WMH, notably in AD, suggesting that WMH may be partly attributable to AD. Thus, firstly, neuropathological studies demonstrate heterogeneity in WMH histology, with indications of a link between tau pathology, Wallerian degeneration, and WMH severity.
View Article and Find Full Text PDFBiomarkers.
Alzheimers Dement
December 2024
Cognitive Impairment Diagnosis and Dementia Prevention Unit, Peruvian Institute of Neurosciences, Lima, Lima, Peru.
Background: The worldwide prevalence of Alzheimer's Disease (AD) surpasses 55 million, with Latin America reaching 11%, driven by demographic changes. Precise diagnosis necessitates neuroimaging, particularly magnetic resonance imaging (MRI). However, low- to middle-income countries face challenges in MRI accessibility due to limited imaging equipment and a shortage of specialized healthcare professionals trained in neuroimaging.
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