AI Article Synopsis
- Injectable hydrogels are minimally invasive carriers that can deliver cells, drugs, or biomolecules for various diseases, created from synthetic or natural polymers.
- They are already clinically approved for use in treating burn wounds and in bone and cartilage reconstruction but are being explored for liver delivery in pre-clinical models.
- The article discusses the design and delivery strategies for these hydrogels, their potential in liver regeneration, associated clinical translation challenges, and possible solutions to address these issues.
Article Abstract
Injectable hydrogels are a sub-type of hydrogels which can be delivered into the host in a minimally invasive manner. They can act as carriers to encapsulate and deliver cells, drugs or active biomolecules across several disease conditions. Polymers, either synthetic or natural, or even a combination of the two, can be used to create injectable hydrogels. Clinically approved injectable hydrogels are being used as dressings for burn wounds, bone and cartilage reconstruction. Injectable hydrogels have recently gained tremendous attention for their delivery into the liver in pre-clinical models. However, their efficacy in clinical studies remains yet to be established. In this article, we describe principles for the design of these injectable hydrogels, delivery strategies and their potential applications in facilitating liver regeneration and ameliorating injury. We also discuss the several constraints related to translation of these hydrogels into clinical settings for liver diseases and deliberate some potential solutions to combat these challenges.
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| http://dx.doi.org/10.1002/asia.202401106 | DOI Listing |
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