The "snowflake sign" in liver brucellosis refers to a characteristic appearance on radiological imaging. It is caused by a calcified granuloma within the liver, resulting from a chronic Brucella infection. This calcification often has a distinctive "snowflake" pattern due to its radiating, irregular shape. This sign can be a valuable clue in diagnosing hepatic brucellosis, especially in regions where the disease is endemic.

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http://dx.doi.org/10.1007/s00261-024-04700-2DOI Listing

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