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Biophysical and biochemical evidence for the role of acetate kinases (AckAs) in an acetogenic pathway in pathogenic spirochetes.
PLoS One
January 2025
Department of Microbiology, UT Southwestern Medical Center, Dallas, TX, United States of America.
Unraveling the metabolism of Treponema pallidum is a key component to understanding the pathogenesis of the human disease that it causes, syphilis. For decades, it was assumed that glucose was the sole carbon/energy source for this parasitic spirochete. But the lack of citric-acid-cycle enzymes suggested that alternative sources could be utilized, especially in microaerophilic host environments where glycolysis should not be robust.
View Article and Find Full Text PDFBackground: Alzheimer's and Parkinson's disease are the most common neurodegenerative diseases. In the current study, we explored the potential of blood-based markers to differentiate Alzheimer's disease (AD) and Parkinson's disease (PD) from healthy controls using ELISA assays via measuring the serum level of α-Syn and panels of inflammatory cytokines in the small pilot cohort of Egyptian volunteers. With the ongoing genetic studies, upcoming data suggest that it is not trivial to revisit the findings reported in specific populations to be tested in each ancestor of different genetic and environmental backgrounds.
View Article and Find Full Text PDFNovel insights into the role of gut microbiota and its metabolites in diabetic chronic wounds.
FASEB J
January 2025
Department of Endocrinology, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, P.R. China.
Wounds in patients with diabetes present significant physical and economic challenges due to impaired healing and prolonged inflammation, exacerbated by complex interactions between microbes. Especially, the development and healing of diabetic foot ulcers (DFUs) remain an urgent clinical problem. The human gut harbors a vast microbial ecosystem comprising intestinal flora and their metabolic products.
View Article and Find Full Text PDFBackground: Lifestyle factors have been studied for their role in dementia, but few have comprehensively assessed both Alzheimer's disease (AD) and cerebrovascular disease (CBVD) pathologies. This study innovatively integrates AD, CBVD, and cognitive composite scores (CCS) within the same cohort to investigate the association of the Life Simple Seven (LS7) score with a broad spectrum of dementia-related outcomes. Our research aims to unravel the intricate relationships between lifestyle and various dementia pathologies, challenging conventional research paradigms.
View Article and Find Full Text PDFAutophagy intersection: Unraveling the role of the SNARE complex in lysosomal fusion in Alzheimer's disease.
J Alzheimers Dis
January 2025
School of Medicine, Chongqing University, Chongqing, P.R. China.
Autophagy is a fundamental cellular process critical for maintaining neuronal health, particularly in the context of neurodegenerative diseases such as Alzheimer's disease (AD). This review explores the intricate role of the SNARE complex in the fusion of autophagosomes with lysosomes, a crucial step in autophagic flux. Disruptions in this fusion process, often resulting from aberrant SNARE complex function or impaired lysosomal acidification, contribute to the pathological accumulation of autophagosomes and lysosomes observed in AD.
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