Objectives: The Curricular Outcomes and Entrustable Professional Activities learning outcome of Cultural and Structural Humility was updated, prompting programs to evaluate how this content is included. The authors reviewed relevant literature published within the past 10 years (2014-2024) and provided a summary and relevant recommendations, as well as resources.
Findings: Calls to action were made within the Academy for programs to develop a holistic programmatic approach to developing students' cultural and structural humility. Current shortcomings identified were that most programs incorporated related competencies into their curriculum at the introduction level; lacked intentional development of related skills and behaviors, instead focusing on knowledge and attitudes; seldomly used validated, reliable, and standardized assessments; and allowed this work to fall on a few designated experts rather than all faculty and preceptors.
Summary: Programs should aim for a holistic approach to prepare graduates to practice with cultural and structural humility, which should begin with creating structures to support it, such as appointment of an administrator or a diversity, equity, and inclusion committee. Integration of Cultural and Structural Humility content should be intentional and spiraled, with competencies mapped across didactic, experiential, and cocurricular activities at all learning levels to ensure development of knowledge, skills, attitudes, and behaviors. Students should have multiple assessment opportunities, including formative and summative, and programs should use standardized, valid, and reliable assessment tools. Intentional development of all faculty, preceptors, and students is critical for success. Institutions are encouraged to share their initiatives with the Academy.
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http://dx.doi.org/10.1016/j.ajpe.2024.101329 | DOI Listing |
J Biomed Mater Res A
January 2025
Faculty of Materials Science and Engineering, Warsaw University of Technology, Warsaw, Poland.
Bone tissue regeneration can be affected by various architectonical features of 3D porous scaffold, for example, pore size and shape, strut size, curvature, or porosity. However, the design of additively manufactured structures studied so far was based on uniform geometrical figures and unit cell structures, which often do not resemble the natural architecture of cancellous bone. Therefore, the aim of this study was to investigate the effect of architectonical features of additively manufactured (aka 3D printed) titanium scaffolds designed based on microtomographic scans of fragments of human femurs of individuals of different ages on in vitro response of human bone-derived mesenchymal stem cells (hMSC).
View Article and Find Full Text PDFBiochem Mol Biol Educ
January 2025
Heritage University, Toppenish, Washington, USA.
The impact of Covid-19 pandemic has dramatically shifted the education landscape between recent college and university graduates and pathways to graduate degrees. In my perspective article, I wish to share the challenges, reflections, and a call-to-action framework in ways we can support and advocate for postbaccalaureate persons excluded because of their ethnicity of race, or from a structurally marginalized community or PEERS through the lens of mindfulness, humility, reflection, and deep listening. Through cross-institutional community network support, culturally responsive mentoring of postbaccalaureate PEERS is one of the key dimensions in empowering communities toward health, environmental, and social justice.
View Article and Find Full Text PDFOsteoarthritis, a major global cause of pain and disability, is driven by the irreversible degradation of hyaline cartilage in joints. Cartilage tissue engineering presents a promising therapeutic avenue, but success hinges on replicating the native physiological environment to guide cellular behavior and generate tissue constructs that mimic natural cartilage. Although electrical stimulation has been shown to enhance chondrogenesis and extracellular matrix production in 2D cultures, the mechanisms underlying these effects remain poorly understood, particularly in 3D models.
View Article and Find Full Text PDFKidney explant cultures are traditionally carried out at air-liquid interfaces, which disrupts 3D tissue structure and limits interpretation of developmental data. To overcome this limitation, we developed a 3D culture technique using hydrogel embedding to capture morphogenesis in real time. We show that 3D culture better approximates -like niche spacing and dynamic tubule tip rearrangement, as well as -like presentation of branching defects under perturbations to glial cell-derived neurotrophic factor (GDNF)- RE arranged during T ransfection (RET) tyrosine kinase signaling.
View Article and Find Full Text PDFUnderstanding the mechanisms of hypoblast development and its role in the implantation is critical for improving farm animal reproduction, but it is hampered by the lack of research models. Here we report that a chemical cocktail (FGF4, BMP4, IL-6, XAV939, and A83-01) enables de novo derivation and long-term culture of bovine extraembryonic endoderm cells (bXENs). Transcriptomic and epigenomic analyses confirmed the identity of bXENs and revealed that they are resemble hypoblast lineages of early bovine peri-implantation embryos.
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