Clin Chim Acta
Centre for Nano-Biosensors, Department of Prosthodontics, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Chennai, 600077, Tamil Nadu, India. Electronic address:
Published: January 2025
Viruses pose a significant threat to global public health, underscoring the urgent need for rapid, accurate, and sensitive diagnostic methods for timely detection and intervention. The demand for efficient diagnostics that can detect a wide range of viral pathogens has never been greater. In this context, metal nanoparticle-based biosensors have emerged as a promising solution, offering exceptional sensitivity for detecting various analytes, including nucleic acids (DNA/RNA), proteins, and other biomarkers associated with pathogens. These biosensors are particularly critical for the development of point-of-care (POC) diagnostic tools, enabling early detection of infectious agents. This review explores recent advancements in nanoparticle (NP)-based biosensors that utilize noble metals like gold (Au), silver (Ag), and platinum (Pt) for viral pathogen detection, focusing on viruses such as SARS-CoV, HIV, hepatitis, influenza, and Zika. It highlights the role of NP-based electrochemical sensors and compares traditional and contemporary detection techniques. The review also examines key performance metrics such as limits of detection (LOD), linear detection ranges, cost-effectiveness, and accessibility, with a special emphasis on their application in POC diagnostics. The aim is to provide researchers with valuable insights into the development of next-generation NP-based biosensors, facilitating the creation of innovative diagnostic technologies for viral diseases.
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http://dx.doi.org/10.1016/j.cca.2024.120054 | DOI Listing |
J Agric Food Chem
December 2024
School of Environmental and Chemical Engineering, Jiangsu University of Science and Technology, Zhenjiang, Jiangsu Province 212003, PR China.
Chloramphenicol (CAP), an aminoalcohol antibiotic, exerts its action on bacterial ribosomes, thereby obstructing protein synthesis. However, the use of CAP in husbandry may lead to its excessive accumulation in animal-derived food products. This presents potential risks to consumer health.
View Article and Find Full Text PDFClin Chim Acta
January 2025
Centre for Nano-Biosensors, Department of Prosthodontics, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Chennai, 600077, Tamil Nadu, India. Electronic address:
Viruses pose a significant threat to global public health, underscoring the urgent need for rapid, accurate, and sensitive diagnostic methods for timely detection and intervention. The demand for efficient diagnostics that can detect a wide range of viral pathogens has never been greater. In this context, metal nanoparticle-based biosensors have emerged as a promising solution, offering exceptional sensitivity for detecting various analytes, including nucleic acids (DNA/RNA), proteins, and other biomarkers associated with pathogens.
View Article and Find Full Text PDFSensors (Basel)
September 2024
Thayer School of Engineering, Dartmouth College, Hanover, NH 03755, USA.
Magnetic nanoparticles (MNPs) can be functionalized with antibodies to give them an affinity for a biomarker of interest. Functionalized MNPs (fMNPs) cluster in the presence of a multivalent target, causing a change in their magnetization. Target concentration can be proportional to the 3rd harmonic phase of the fMNP magnetization signal.
View Article and Find Full Text PDFInt J Nanomedicine
September 2024
Department of Endocrinology, The Second Hospital of Jilin University, Changchun, 13000, People's Republic of China.
The endocrine system regulates many biological systems, and disruptions may result in disorders, such as diabetes, thyroid dysfunction, Cushing's syndrome, and obesity. The total incidence of endocrine illnesses was found to be 47.4%, excluding type 2 diabetes mellitus, with a significant frequency of newly diagnosed endocrine disorders.
View Article and Find Full Text PDFCureus
July 2024
Department of Physiology, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences (SIMATS) Saveetha University, Chennai, IND.
Background The fabrication of titanium carbide (TiC)-cobalt sulfide (CoS)-based biosensors with high sensitivity and selectivity can change the biosensor manufacturing industry completely. Molecular and clinical diagnostics, disease progression monitoring, and drug discovery could utilize these sensors for early biomarker detection. MXene (TiC) is a two-dimensional material with exceptional electrical conductivity, hydrophilicity, great thermal stability, large interlayer spacing, and a high surface area.
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