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ANGPTL4-mediated inflammation: A new mechanism of disease and therapeutic approach for rheumatoid arthritis.
Mol Ther
December 2024
Laboratory of Skeletal Biomedicine, IBIMA Plataforma BIONAND, Department of Cell Biology, Genetics and Physiology, University of Málaga, 29071 Málaga, Spain. Electronic address:
Knockdown of angiopoietin-like 4 suppresses sepsis-induced acute lung injury by blocking the NF-κB pathway activation and hindering macrophage M1 polarization and pyroptosis.
Toxicol In Vitro
February 2024
Department of Infection Control, Beijing Tiantan Hospital, Capital Medical University, Beijing, China. Electronic address:
Objective: Sepsis-induced acute lung injury (ALI) is a life-threatening disease. Macrophage pyroptosis has been reported to exert function in ALI. We aimed to investigate the mechanisms of ANGPTL4-mediated cell pyroptosis in sepsis-induced ALI, thus providing new insights into the pathogenesis and prevention and treatment measures of sepsis-induced ALI.
View Article and Find Full Text PDFANGPTL4 Regulates Psoriasis Modulating Hyperproliferation and Inflammation of Keratinocytes.
Front Pharmacol
July 2022
Department of Dermatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
: Psoriasis is characterized by keratinocyte proliferation and massive inflammatory leukocytes infiltration, affecting 0.14%-1.99% of the world's population.
View Article and Find Full Text PDFSingle-cell analysis of skin immune cells reveals an Angptl4-ifi20b axis that regulates monocyte differentiation during wound healing.
Cell Death Dis
February 2022
Lee Kong Chian School of Medicine, Nanyang Technological University Singapore, 11 Mandalay Road, Singapore, 308232, Singapore.
The persistent inflammatory response at the wound site is a cardinal feature of nonhealing wounds. Prolonged neutrophil presence in the wound site due to failed clearance by reduced monocyte-derived macrophages delays the transition from the inflammatory to the proliferative phase of wound healing. Angiopoietin-like 4 protein (Angptl4) is a matricellular protein that has been implicated in many inflammatory diseases.
View Article and Find Full Text PDFAngiopoietin-like 4 Mediates Colonic Inflammation by Regulating Chemokine Transcript Stability via Tristetraprolin.
Sci Rep
March 2017
School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, Singapore 637551, Singapore.
Many gastrointestinal diseases exhibit a protracted and aggravated inflammatory response that can lead to hypercytokinaemia, culminating in extensive tissue damage. Recently, angiopoietin-like 4 (ANGPTL4) has been implicated in many inflammation-associated diseases. However, how ANGPTL4 regulates colonic inflammation remains unclear.
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